CCR4/CD194 cDNA Clones Research Reagents

All CCR4/CD194 reagents are produced in house and quality controlled, including 35 CCR4/CD194 Gene, 2 CCR4/CD194 qPCR. All CCR4/CD194 reagents are ready to use.

CCR4/CD194 cDNA Clone (35)

BC071751

In expression vector

In lentiviral vector

NM_009916.2

In expression vector

In lentiviral vector

NM_133532.2

克隆载体 cDNA 产品

In lentiviral vector

XM_001098807.2

克隆载体 cDNA 产品

In lentiviral vector

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CCR4/CD194 分子背景

CCR4 is a chemokine receptor that has a critical role in immune cell trafficking. T-helper type 2 cells (Th2), regulatory T cells (Treg), interluekin-17–producing T-helper cells (Th17), and skin-homing memory T cells express CCR4 on their surface and migrate toward the chemokines CCL17 and CCL22. CCR4, a C-C type chemokine receptor, has previously been focused on its biological function in immunopathogenesis of hematological tumors. To date, relatively little attention has been paid to the role of CCR4 in promoting metastasis of some solid tumors, including gastric cancer. Our group has shown that the lymphocyte-rich gastric cancers tend to be more frequently positive for CCR4, and found a novel role of CCR4 in tumor-induced immunosuppression, indicating various expression profiles of CCR4 in gastric cancer tissues and multifunctional roles of this molecule in gastric cancer progression.

CCR4/CD194 参考文献

  • Yang Y, Du L, Yang X, et al. Aberrant CCR4 Expression Is Involved in Tumor Invasion of Lymph Node-Negative Human Gastric Cancer. Tang C-H, ed. PLoS ONE. 2015;10(3):e0120059. doi:10.1371/journal.pone.0120059.
  • Nakagawa M, Schmitz R, Xiao W, et al. Gain-of-function CCR4 mutations in adult T cell leukemia/lymphoma. The Journal of Experimental Medicine. 2014;211(13):2497-2505.

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