CD122/IL2RB Proteins, cDNA Clones Research Reagents

IL2RB (Interleukin 2 Receptor Subunit Beta, also known as CD122; IMD63; IL15RB; P70-75), located on 22q12.3, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, and rat. The gene produces a 61117 Da protein composed of 551 amino acids. The IL2R, which is involved in T cell-mediated immune responses, is present in 3 forms concerning the ability to bind IL2. Both the intermediate and high-affinity forms of IL2RB are involved in receptor-mediated endocytosis and transduction of mitogenic signals from IL2.

CD122/IL2RB Protein (11)

    CD122/IL2RB cDNA Clone (65)

    NM_000878.4

    克隆载体 cDNA 产品

    In lentiviral vector

    NM_008368.3

    克隆载体 cDNA 产品

    In lentiviral vector

    NM_013195.1

    克隆载体 cDNA 产品

    In lentiviral vector

    XM_002798371.1

    克隆载体 cDNA 产品

    In lentiviral vector

    XM_003431504.1

    克隆载体 cDNA 产品

    In lentiviral vector

    CD122/IL2RB Lysate (11)

      CD122/IL2RB 分子背景

      Interleukin-2 receptor (IL-2R) also known as High-affinity IL-2 receptor subunit beta, IL-2 receptor subunit beta, and IL-2RB, is involved in T cell-mediated immune responses. CD122/IL-2RB is present in 3 forms concerning the ability to bind interleukin 2. The low-affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high-affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high-affinity forms of CD122/IL-2RB are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. CD122/IL-2RB expression was restricted to the earliest B220+ cells (CD43+CD24-; prepro B cells; fraction A) that proliferate vigorously to IL-2 in the absence of any stromal cells, but not to IL-15. The high-affinity form of this receptor is expressed on activated T lymphocytes, activated B lymphocytes, and activated macrophages. CD122/IL-2RB plays a role in regulating normal lymphocyte development.

      CD122/IL2RB 参考文献

      • Foss F. (2006) Clinical experience with denileukin diftitox (ONTAK). Semin Oncol. 33(1 Suppl 3): 11-6.
      • Sprent J, et al. (2001) T cell death and memory. Science. 293(5528): 245-8.
      • Teshigawara K, et al. (1987) Interleukin 2 high-affinity receptor expression requires two distinct binding proteins. J Exp Med. 165 (1): 223-38.

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