CD13 Proteins, Antibodies, cDNA Clones Research Reagents

All CD13 reagents are produced in house and quality controlled, including 14 CD13 Antibody, 17 CD13 Gene, 2 CD13 IP Kit, 2 CD13 Lysate, 2 CD13 Protein, 2 CD13 qPCR. All CD13 reagents are ready to use.

CD13 Protein (2)

    CD13 Antibody (14)

      CD13 cDNA Clone (17)

      NM_001150.2

      In expression vector

      In lentiviral vector

      NM_008486.1

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_031012.1

      克隆载体 cDNA 产品

      CD13 Lysate (2)

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        CD13 分子背景

        Aminopeptidase N (ANPEP or APN), also known as CD13, is a cell-surface metalloprotease located in the small-intestinal and renal microvillar membrane, as well as other plasma membranes. It belongs to the peptidase M1 family. CD13 plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases and is involved in the metabolism of regulatory peptides by diverse cell types. CD13/APN is a potent regulator of angiogenesis which is essential for tumor invasion and metastasis, and its transcription in activated endothelial cells is induced by angiogenic growth factors via the RAS/MAPK pathway. In addition, this enzyme has been shown to participate in antigen processing and presentation, and accordingly, defects in this gene appear to be a cause of various types of leukemia or lymphoma and carcinomas.

        CD13 参考文献

        • Pasqualini R, et al. (2000) Aminopeptidase N is a receptor for tumor-homing peptides and a target for inhibiting angiogenesis.Cancer Res. 60(3): 722-7.
        • Mabjeesh SJ, et al. (2005) Aminopeptidase N gene expression and abundance in caprine mammary gland is influenced by circulating plasma peptide. J Dairy Sci. 88(6): 2055-64.
        • Dunkel B, et al. (2009) Neutrophil and platelet activation in equine recurrent airway obstruction is associated with increased neutrophil CD13 expression, but not platelet CD41/61 and CD62P or neutrophil-platelet aggregate formation. Vet Immunol Immunopathol. 131(1-2): 25-32.

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