CD200 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

All CD200 reagents are produced in house and quality controlled, including 12 CD200 Antibody, 2 CD200 ELISA, 41 CD200 Gene, 6 CD200 Lysate, 7 CD200 Protein, 2 CD200 qPCR. All CD200 reagents are ready to use.

CD200 Protein (7)

    CD200 Antibody (12)

      CD200 ELISA 试剂盒(即用型)& ELISA 抗体对套装(非即用型)(2)

      CD200 cDNA Clone (41)

      NM_005944.5

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_010818.3

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_031518.2

      克隆载体 cDNA 产品

      In lentiviral vector

      XM_001103685.2

      克隆载体 cDNA 产品

      In lentiviral vector

      CD200 Lysate (6)

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        CD200 分子背景

        CD200 (OX-2) is a cell surface glycoprotein that imparts immune privileges by suppressing alloimmune and autoimmune responses through its receptor, CD200R, expressed primarily on myeloid cells. Signals delivered through the CD200:CD200R axis have been shown to play an important role in the regulation of anti-tumor immunity, and overexpression of CD200 has been reported in a number of malignancies, including CLL, as well as on cancer stem cells. The role of CD200-CD200R signaling in immune regulation of the central nervous system has become a popular field of research in recent years. Many studies have shown that there is a close correlation between CD200-CD200R, microglia activation, and Parkinson's disease (PD). The ability of CD200 to suppress myeloid cell activation is critical for maintaining normal tissue homeostasis but may also enhance the survival of migratory neoplastic cells. CD200 and CD200R associate via their respective N-terminal Ig-like domains. CD200 has been characterized as an important immunoregulatory molecule, increased expression of which can lead to decreased transplant rejection, autoimmunity, and allergic disease. Elevated CD200 expression has been reported to be associated with poor prognosis in some human malignancies. Besides, CD200 also plays an important role in prevention of graft rejection, autoimmune diseases and spontaneous abortion.

        CD200 参考文献

        • Minas K, et al. (2006) Is the CD200/CD200 receptor interaction more than just a myeloid cell inhibitory signal? Crit Rev Immunol. 26(3): 213-30.
        • Wang XJ, et al. (2007) CD200-CD200R regulation of microglia activation in the pathogenesis of Parkinson's disease. J Neuroimmune Pharmacol. 2(3): 259-64.
        • Wong KK, et al. (2010) The role of CD200 in immunity to B cell lymphoma. J Leukoc Biol. 88(2): 361-72.

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