CD27 (蛋白 | 抗体 | cDNA 克隆 | ELISA 试剂盒)

All CD27 reagents are produced in house and quality controlled, including 31 CD27 Antibody, 65 CD27 Gene, 9 CD27 Lysate, 11 CD27 Protein, 3 CD27 qPCR. All CD27 reagents are ready to use.

CD27 Protein (11)

    CD27 Antibody (31)

      CD27 cDNA Clone (65)

      NM_001242.4

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_001033126.2

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_001024335.1

      克隆载体 cDNA 产品

      In lentiviral vector

      XM_849371.2

      克隆载体 cDNA 产品

      In lentiviral vector

      XM_001104337.2

      克隆载体 cDNA 产品

      In lentiviral vector

      CD27 Lysate (9)

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        CD27 分子背景

        CD27, also known as TNFRSF7, is a member of the TNF-receptor superfamily limited to cells of the lymphoid lineage, and exists as both a dimeric glycoprotein on the cell surface and as a soluble protein in serum. As a type I transmembrane glycoprotein of about 55 kDa existing as disulfide-linked homodimer, CD27 has been shown to play roles in lymphoid proliferation, differentiation, and apoptosis.It has important role in generation of T cell immunity, and is an apparently robust marker for normal memory B cells. It is a T and B cell co-stimulatory molecule, the activity of CD27 is governed by its TNF-like ligand CD7 on lymphocytes and dendritic cells. The CD27-CD7 interaction is required for Th1 generation responses to differentiation signals and long-term maintenance of T cell immunity, and meanwhile, plays a key role in regulating B-cell differentiation, activation and immunoglobulin synthesis.

        CD27 参考文献

        • Drner T, et al. (2004) Correlation of circulating CD27 high plasma cells and disease activity in systemic lupus erythematosus. Lupus. 13(5): 283-9.
        • Sahota SS, et al. (2009) CD27 in defining memory B-cell origins in Waldenstrm's macroglobulinemia. Clin Lymphoma Myeloma. 9(1): 33-5.
        • Jiang J, et al. (2010) Reduced CD27 expression on antigen-specific CD4+ T cells correlates with persistent active tuberculosis. J Clin Immunol. 30(4): 566-73.

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