CD43 Proteins, Antibodies, cDNA Clones Research Reagents

SPN (Sialophorin) is a protein coding gene located on human chromosome 16p11.2. SPN is also known as LSN, CD43, GALGP and GPL115. The human SPN gene encodes a 40322 Da protein containing 400 amino acids. The SPN protein is biasedly expressed in bone marrow, lymph node and other tissues. Among its related pathways are Cell surface interactions at the vascular wall and Hematopoietic Stem Cells and Lineage-specific Markers. SPN is related to transmembrane signaling receptor activity. SPN is associated with some diseases, including Wiskott-Aldrich Syndrome and Adenoid Basal Cell Carcinoma.

CD43 Protein (2)

    CD43 Antibody (1)

      CD43 cDNA Clone (39)

      NM_001030288.1

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_001037810.1

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_001271086.1

      克隆载体 cDNA 产品

      In lentiviral vector

      CD43 Lysate (2)

        CD43 分子背景

        CD43 is an abundantly expressed molecule on the T-cell surface that shows distinct localization to the migrating T-cell uropod and the distal pole complex (DPC) opposite the immunological synapse via association with the ezrin-radixin-moesin (ERM) family of actin regulatory proteins. CD43 has a 235-amino acid (aa) extracellular domain, a 23-aa transmembrane domain, and a 123-aa cytoplasmic domain, all encoded by a single exon. The intracytoplasmic region of the protein is necessary to transduce signals; it is rich in potentially phosphorylable threonines and serines but lacks tyrosine residues as well as catalytic activity. CD43 engagement on human peripheral blood T cells and monocytes leads to cell activation and proliferation through the generation of second messengers such as diacylglycerol and inositol phosphates, protein kinase C (PKC) activation and Ca2+ mobilization. Besides, CD43 ligation on human T cells induces the association of CD43 with Src family kinases, presumably through the interaction of their Src homology 3 domain with a proline-rich region of the CD43 intracytoplasmic tail. This molecule has been implicated in T cell activation, enhancing T cell response to allogeneic or mitogenic stimulation and CD43-specific signals have been reported to be sufficient to activate T cells in the absence of T cell receptor (TCR) engagement. In summary, CD43 regulates multiple T-cell functions, including T-cell activation, proliferation, apoptosis, and migration.

        CD43 参考文献

        • . Layseca-Espinosa E, et al. (2003) Journal of Leukocyte Biology. 74(6): 1083-93.
        • Cannon JL, et al. (2011) Mol Biol Cell. 22(7):954-63.
        • Pallant A,et al. (1989). Proc Natl Acad Sci. 86 (4): 1328–32.

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