CD50 (蛋白 | 抗体 | cDNA 克隆 | ELISA 试剂盒)

All CD50 reagents are produced in house and quality controlled, including 11 CD50 Antibody, 1 CD50 ELISA, 12 CD50 Gene, 1 CD50 IP Kit, 2 CD50 Lysate, 2 CD50 Protein, 1 CD50 qPCR. All CD50 reagents are ready to use.

CD50 Protein (2)

    CD50 Antibody (11)

      CD50 ELISA 试剂盒(即用型)& ELISA 抗体对套装(非即用型)(1)

      CD50 cDNA Clone (12)

      NM_002162.3

      CD50 qPCR Primer (1)

      CD50 Lysate (2)

        CD50 分子背景

        The protein ICAM-3, also known as CD5, is a member of the intercellular adhesion molecule (ICAM) family consisting three members. It is a DC-SIGN ligand that is constitutively expressed on resting leukocytes, and is thus an important molecule for the first immune response. ICAM-3 comprises of five immunoglobulin-like domains, and binds LFA-1 through its two N-terminal domains. It functions not only as an adhesion molecule, but also as a potent signalling molecule. ICAM-3 binds to LFA-1 on antigen-presenting cells (APC) stabilizing the T cell-APC interaction, facilitating signaling through the CD3/TCR complex. However, recent evidence using cultured and transformed T cells suggests ICAM-3 may also function in signaling. It has been reported that CD5 molecule can play a role in developing functionally mature T lymphocytes and its expression increases during the maturation process of T lymphocytes. In addition, the interactions of ICAM-3 and LFA-1 facilitate HIV-1- induced virological synapse formation between T cells. ICAM-3 is associated with an increase of cellular radio-resistance and cancer cell proliferation. It could be considered as a candidate for anti-cancer drug development and as a cancer diagnostic marker.

        CD50 参考文献

        • Berney SM, et al. (1999) ICAM-3 (CD50) cross-linking augments signaling in CD3-activated peripheral human T lymphocytes. J Leukoc Biol. 65(6): 867-74.
        • van Buul JD, et al. (2004) ICAM-3 activation modulates cell-cell contacts of human bone marrow endothelial cells. J Vasc Res. 41(1): 28-37.
        • Sugino H. (2005) ICAM-3, a ligand for DC-SIGN, was duplicated from ICAM-1 in mammalian evolution, but was lost in the rodent genome. FEBS Lett. 579(13): 2901-6.
        • Park JK, et al. (2010) ICAM-3 enhances the migratory and invasive potential of human non-small cell lung cancer cells by inducing MMP-2 and MMP-9 via Akt and CREB. Int J Oncol. 36(1): 181-92.

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