CD70 Proteins, Antibodies, cDNA Clones Research Reagents

All CD70 reagents are produced in house and quality controlled, including 1 CD70 Antibody, 52 CD70 Gene, 6 CD70 Lysate, 7 CD70 Protein, 2 CD70 qPCR. All CD70 reagents are ready to use.

CD70 Protein (7)

    CD70 Antibody (1)

      CD70 cDNA Clone (52)

      NM_001252.3

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_011617.2

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_001106878.1

      克隆载体 cDNA 产品

      In lentiviral vector

      XM_001088935.2

      克隆载体 cDNA 产品

      In lentiviral vector

      CD70 qPCR Primer (2)

      CD70 Lysate (6)

        CD70 分子背景

        CD70, a member of the tumor necrosis factor superfamily, is restricted to activated T-and B-lymphocytes and mature dendritic cells. Binding of CD70 to its receptor, CD27, is important in priming, effector functions, differentiation and memory formation of T-cells as well as plasma and memory B-cell generation. Tight control of CD70 expression is required to prevent lethal immunodeficiency. By selective transcription, CD70 is largely confined to activated lymphocytes and dendritic cells (DC). As a type II transmembrane receptor, CD70 is normally expressed on a subset of B, T and NK cells, where it plays a costimulatory role in immune cell activation. Immunohistochemical analysis of CD70 expression in multiple carcinoma types. The restricted expression pattern of CD70 in normal tissues and its widespread expression in various malignancies makes it an attractive target for antibody-based therapeutics. Investigations to exploit CD70 as a cancer target have lead to the identification of potential antibody-based clinical candidates.

        CD70 参考文献

        • Adam PJ, et al. (2006) CD70 (TNFSF7) is expressed at high prevalence in renal cell carcinomas and is rapidly internalised on antibody binding. Br J Cancer. 95(3): 298-306.
        • Keller AM, et al. (2007) Costimulatory ligand CD70 is delivered to the immunological synapse by shared intracellular trafficking with MHC class II molecules. Proc Natl Acad Sci U S A. 104(14): 5989-94.
        • Grewal IS. (2008) CD70 as a therapeutic target in human malignancies. Expert Opin Ther Targets. 12(3): 341-51.
        • Boursalian TE, et al. (2009) Targeting CD70 for human therapeutic use. Adv Exp Med Biol. 647: 108-19.

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