CD89 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

All CD89 reagents are produced in house and quality controlled, including 11 CD89 Antibody, 1 CD89 ELISA, 26 CD89 Gene, 2 CD89 Lysate, 2 CD89 Protein, 2 CD89 qPCR. All CD89 reagents are ready to use.

CD89 Protein (2)

    CD89 Antibody (11)

      CD89 ELISA 试剂盒(即用型)& ELISA 抗体对套装(非即用型)(1)

      CD89 cDNA Clone (26)

      NM_002000.2

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_201992.1

      克隆载体 cDNA 产品

      In lentiviral vector

      CD89 qPCR Primer (2)

      CD89 Lysate (2)

        CD89 分子背景

        FCAR, also called FcαRI or CD89, is a type I transmembrane receptor for Fc region of IgA which is the most abundant immunoglobulin in mucosal areas but is only the second most common antibody isotype in serum. This receptor is present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, especially phagocytes located in mucosal areas. Upon ligand IgA binding, FcαRI associates with the FcR γ signaling molecule bearing the immunoreceptor tyrosine-based activation motif (ITAM) through a unique charge-based mechanism and triggers multiple cell-mediated immune responses. It has been reported that Fc RI is a dual-function receptor that can mediate both inflammatory and anti-inflammatory responses depending on the type of interaction with its ligand. Sustained aggregation of FCAR results in activation of target-cell functions such as antigen presentation and cytokine release. In contrast, Monomeric targeting with serum IgA or with a variety of anti-FcαRI Fab fragments triggers an inhibitory response and additionally induces apoptosis. FcαRI thus play an fundamental role in preventing tumor development and growth, as well as in controlling inflammation.

        CD89 参考文献

        • Maliszewski, C.R. et al., 1990, J. Exp. Med. 172: 1665-1672.

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