CD98 Proteins, Antibodies, cDNA Clones Research Reagents

SLC3A2 (Solute Carrier Family 3 Member 2) is a protein coding gene located on human chromosome 11q12.3. SLC3A2 is also known as 4F2, CD98, MDU1, 4F2HC, 4T2HC, NACAE and CD98HC. The human SLC3A2 gene encodes a 67994 Da protein containing 630 amino acids. The SLC3A2 protein is ubiquitously expressed in kidney, bone marrow and other tissues. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Collagen chain trimerization. SLC3A2 is related to neutral amino acid transmembrane transporter activity. SLC3A1 is an important paralog of SLC3A2 gene. SLC3A2 is associated with some diseases, including Lysinuric Protein Intolerance and Cystinuria.

CD98 Protein (4)

    CD98 Antibody (11)

      CD98 cDNA Clone (54)

      NM_001013251.2

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_001161413.1

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_019283.1

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_001285242.1

      克隆载体 cDNA 产品

      In lentiviral vector

      CD98 Lysate (4)

        CD98 分子背景

        4F2 cell-surface antigen heavy chain, also known as 4F2 heavy chain antigen, Lymphocyte activation antigen 4F2 large subunit, CD98, SLC3A2 and MDU1, is a single-pass type I I membrane protein that belongs to the SLC3A transporter family. SLC3A2 / MDU1 is expressed ubiquitously in all tissues tested with highest levels detected in kidney, placenta and testis and weakest level in thymus. During gestation, expression in the placenta is significantly stronger at full-term than at the mid-trimester stage. SLC3A2 / MDU1 is expressed in HUVECS and at low levels in resting peripheral blood T-lymphocytes and quiescent fibroblasts. It is expressed in fetal liver and in the astrocytic process of primary astrocytic gliomas. SLC3A2 / MDU1 is also expressed in retinal endothelial cells and in the intestinal epithelial cell line Caco2-BBE. SLC3A2 / MDU1 is required for the function of light chain amino-acid transporters. It is involved in sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan. SLC3A2 / MDU1 is involved in guiding and targeting of LAT1 and LAT2 to the plasma membrane. When associated with SLC7A6 or SLC7A7, SLC3A2 / MDU1 acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. SLC3A2 / MDU1 plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. It is required for normal and neoplastic cell growth. When associated with SLC7A5/LAT1, SLC3A2 / MDU1 is also involved in the transport of L-DOPA across the blood-brain barrier, and that of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane in tissues such as placenta.

        CD98 参考文献

        • Torrents D. et al., 1998, J Biol Chem. 273: 32437-45.
        • Pfeiffer R. et al., 1999, EMBO J. 18: 49-57.
        • Broeer A. et al., 2000, Biochem J. 349: 787-95.
        • Yanagida O. et al., 2001, Biochim Biophys Acta. 1514: 291-302.
        • Broeer A. et al., 2001, Biochem J. 355: 725-31.
        • Fort J. et al., 2007, J Biol Chem. 282: 31444-52.
        • Mayya V. et al., 2009, Sci Signal. 2: RA46-RA46.

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