CEACAM1 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

All CEACAM1 reagents are produced in house and quality controlled, including 26 CEACAM1 Antibody, 1 CEACAM1 ELISA, 15 CEACAM1 Gene, 5 CEACAM1 Lysate, 5 CEACAM1 Protein, 2 CEACAM1 qPCR. All CEACAM1 reagents are ready to use.

CEACAM1 Protein (5)

    CEACAM1 Antibody (26)

      CEACAM1 ELISA 试剂盒(即用型)& ELISA 抗体对套装(非即用型)(1)

      CEACAM1 cDNA Clone (15)

      NM_001712.4

      克隆载体 cDNA 产品

      In expression vector

      NM_001039186.1

      克隆载体 cDNA 产品

      In lentiviral vector

      CEACAM1 Lysate (5)

        CEACAM1 分子背景

        The carcinoembryonic-antigen-related cell-adhesion molecule (CEACAM) family of proteins has been implicated in various intercellular-adhesion and intracellular-signalling-mediated effects that govern the growth and differentiation of normal and cancerous cells. CEACAM1, also known as biliary glycoprotein I (BGP I) and CD66a, is a member of the carcinoembryonic antigen (CEA) gene family which belongs to the immunoglobulin superfamily. The highly glycosylated CEACAM1 contains one N-terminal V-type Ig-like domain and three C2-type Ig-like domains within its ECD, and one ITIM motif and a calmodulin binding site in the cytoplasmic region. CEACAM1 is a surface glycoprotein expressed on various blood cells, epithelial cells, and vascular cells. It was described as an adhesion molecule mediating cell adhesion via both homophilic and heterophilic manners, and was detected on leukocytes, epithelia, and endothelia. Studies have revealed that CEACAM1 performs actions in multiple cellular processes including tissue differentiation, angiogenesis, apoptosis, metastasis, as well as the modulation of innate and adaptive immune responses.

        CEACAM1 参考文献

        • Gray-Owen SD, et al. (2006) CEACAM1: contact-dependent control of immunity. Nat Rev Immunol. 6(6): 433-46.
        • Gu A, et al. (2009) Role of Ceacam1 in VEGF induced vasculogenesis of murine embryonic stem cell-derived embryoid bodies in 3D culture. Exp Cell Res. 315(10): 1668-82.
        • Wong C, et al. (2009) CEACAM1 negatively regulates platelet-collagen interactions and thrombus growth in vitro and in vivo. Blood. 113(8): 1818-28.

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