CLEC-2 Proteins, Antibodies, cDNA Clones Research Reagents

All CLEC-2 reagents are produced in house and quality controlled, including 3 CLEC-2 Antibody, 27 CLEC-2 Gene, 2 CLEC-2 Lysate, 2 CLEC-2 Protein, 2 CLEC-2 qPCR. All CLEC-2 reagents are ready to use.

CLEC-2 Protein (2)

    CLEC-2 Antibody (3)

      CLEC-2 cDNA Clone (27)

      NM_016509.3

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_019985.2

      克隆载体 cDNA 产品

      In lentiviral vector

      CLEC-2 Lysate (2)

        CLEC-2 分子背景

        CLEC1B, also known as CLEC2, is a C-type lectin-like receptor expressed in myeloid cells and NK cells. Natural killer (NK) cells express multiple calcium-dependent (C-type) lectin-like receptors, such as CD94 and NKG2D, that interact with major histocompatibility complex class I molecules and either inhibit or activate cytotoxicity and cytokine secretion. CLEC2 acts as a receptor for the platelet-aggregating snake venom protein rhodocytin. Rhodocytin binding leads to tyrosine phosphorylation and this promotes the binding of spleen tyrosine kinase (Syk) and initiation of downstream tyrosine phosphorylation events and activation of PLC-gamma-2. CLEC2 contains 1 C-type lectin domain and is expressed preferentially in the liver. It acts as an attachment factor for human immunodeficiency virus type 1 (HIV-1) and facilitates its capture by platelets.

        CLEC-2 参考文献

        • Suzuki-Inoue K, et al. (2007) Involvement of the snake toxin receptor CLEC-2, in podoplanin-mediated platelet activation, by cancer cells. J Biol Chem. 282(36):25993-6001.
        • Watson AA, et al. (2007) The crystal structure and mutational binding analysis of the extracellular domain of the platelet-activating receptor CLEC-2. J Biol Chem. 282(5):3165-72.
        • Chaipan C, et al. (2006) DC-SIGN and CLEC-2 mediate human immunodeficiency virus type 1 capture by platelets. J Virol. 80(18):8951-60.

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