CREB (蛋白 | 抗体 | cDNA 克隆 | ELISA 试剂盒)

All CREB reagents are produced in house and quality controlled, including 6 CREB Antibody, 30 CREB Gene, 1 CREB IP Kit, 2 CREB qPCR. All CREB reagents are ready to use.

CREB Antibody (6)

    CREB cDNA Clone (30)

    NM_004379.2

    克隆载体 cDNA 产品

    In lentiviral vector

    NM_001037726.1

    克隆载体 cDNA 产品

    In lentiviral vector

    CREB 分子背景

    CAMP responsive element binding protein 1, also known as CREB-1, plays multiple functions as a transcription factor in gene regulation. This protein is a CREB transcription factor that is a member of the leucine zipper family of DNA-binding proteins. CREB1 proteins are also known to be expressed in several spliced isoforms that act as transcriptional activators or repressors. The activator isoforms, possessing the functional domains for kinase induction and for interaction with other transcriptional regulators, act as transcriptional activators.The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. CREB-1 has a complex influence on behavioural responses to drugs of abuse which varies depending on the brain region in which it is expressed. CREB-1 is important for serotonin (5-HT)-induced long-term facilitation (LTF) of the sensorimotor synapse in Aplysia.

    CREB 参考文献

    • Sadamoto H, et al. (2011) Direct observation of dimerization between different CREB1 isoforms in a living cell. PLoS One. 6 (6): e20285.
    • Liu RY, et al. (2011) The requirement for enhanced CREB1 expression in consolidation of long-term synaptic facilitation and long-term excitability in sensory neurons of Aplysia. J Neurosci. 31 (18): 6871-9.
    • Hoeffler JP, et al. (1988) Cyclic AMP-responsive DNA-binding protein: structure based on a cloned placental cDNA. Science. 242 (4884): 1430-3.

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