DC-SIGN Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

All DC-SIGN reagents are produced in house and quality controlled, including 13 DC-SIGN Antibody, 2 DC-SIGN ELISA, 26 DC-SIGN Gene, 3 DC-SIGN Lysate, 3 DC-SIGN Protein, 1 DC-SIGN qPCR. All DC-SIGN reagents are ready to use.

DC-SIGN Protein (3)

    DC-SIGN Antibody (13)

      DC-SIGN ELISA 试剂盒(即用型)& ELISA 抗体对套装(非即用型)(2)

      DC-SIGN cDNA Clone (26)

      NM_021155.2

      克隆载体 cDNA 产品

      In lentiviral vector

      AY040319.1

      克隆载体 cDNA 产品

      In lentiviral vector

      DC-SIGN qPCR Primer (1)

      DC-SIGN Lysate (3)

        DC-SIGN 分子背景

        Dendritic cell (DC)-specific intercellular adhesion molecule 3 (ICAM-3) grabbing nonintegrin (DC-SIGN), also known as CD29, is a type II transmembrane protein on DCs with a C-type lectin extracellular domain, is capable of binding ICAM-3 on resting T cells in the secondary lymphoid organs, providing the initial contact between these cells during the establishment of cell-mediated immunity. It is not only a pattern recognition receptor but implicated in immunoregulation of DCs. It has important role in mediating DC adhesion, migration, inflammation, activating primary T cell, triggering immune response and participating in immune escape of pathogens and tumors. DC-SIGN also mediates capture and internalization of viral, bacterial, and fungal pathogens by dendritic cells, such as HIV-1, Ebola virus, cytomegalovirus, Dengue virus, and hepatitis C virus. DC-SIGN is unique in that it regulates adhesion processes, such as DC trafficking and T-cell synapse formation, as well as antigen capture. Moreover, even though several C-type lectins have been shown to bind HIV-1, DC-SIGN does not only capture HIV-1 but also protects it in early endosomes allowing HIV-1 transport by DC to lymphoid tissues, where it enhances trans infection of T cells.

        DC-SIGN 参考文献

        • Geijtenbeek TB, et al. (2002) DC-SIGN, a C-type lectin on dendritic cells that unveils many aspects of dendritic cell biology. J Leukoc Biol. 71(6): 921-31.
        • Masso M. (2003) DC-SIGN points the way to a novel mechanism for HIV-1 transmission. MedGenMed. 5(2): 2.
        • Zhou T, et al. (2006) DC-SIGN and immunoregulation. Cell Mol Immunol. 3(4): 279-83.

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