DDC Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

All DDC reagents are produced in house and quality controlled, including 8 DDC Antibody, 1 DDC ELISA, 32 DDC Gene, 2 DDC Lysate, 2 DDC Protein, 2 DDC qPCR. All DDC reagents are ready to use.

DDC Protein (2)

    DDC Antibody (8)

      DDC ELISA 试剂盒(即用型)& ELISA 抗体对套装(非即用型)(1)

      DDC cDNA Clone (32)

      NM_000790.3

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_000790.4

      In expression vector

      NM_001190448.1

      克隆载体 cDNA 产品

      In lentiviral vector

      DDC Lysate (2)

        DDC 分子背景

        Dopa Decarboxylase (DDC), also known as AADC and Aromatic-L-amino acid decarboxylase, is a 54 kDa member of the group II decarboxylase family of proteins.It is a vitamin B6-dependent homodimeric enzyme that catalyzes the decarboxylation of both L-3,4-dihydroxyphenylalanine (L-DOPA) and L-5-hydroxytryptophan to dopamine and serotonin, respectively, which are major mammalian neurotransmitters and hormones belonging to catecholamines and indoleamines. Since L-DOPA is regularly used to treat the symptoms of Parkinson's disease, the catalytic pathway is of particular research interest. Defects of DDC are associated with severe developmental delay, oculogyric crises (OGC), as well as autosomal recessive disorder AADC deficiency, an early onset inborn error in neurotransmitter metabolism which can lead to catecholamine and serotonin deficiency.

        DDC 参考文献

        • Ichinose, H. et al.,1989,Biochem. Biophys. Res. Commun. 164: 1024-1030.
        • Lisa, J. S. et al., 1992, Genomics 13: 469-471.
        • Moore, P. S. et al.,1996, Biochem. J. 315:249-256.
        • Bertoldi, M. et al., 2003, Biochim. Biophys. Acta. 1647:42-47.
        • Vassilacopoulou, D. et al., 2004, Neurochem. Res. 29: 1817-1823.
        • Ma, J.Z., et al., 2005, Hum. Mol. Genet. 14: 1691-1698.

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