DEC-205 Proteins, Antibodies, cDNA Clones Research Reagents

LY75 (Lymphocyte Antigen 75, also known as CD205; LY-75; CLEC13B; DEC-205; GP200-MR6), located on 2q24.2, is a Protein Coding gene. The gene produces a 198311 Da protein composed of 1722 amino acids. LY75 is a member of the MMR family of multidomain molecules. It contains a signal peptide, a cysteine-rich domain, a fibronectin type-II domain, 10 carbohydrate recognition-like domains, a transmembrane domain, and a cytoplasmic tail. Diseases such as Pneumonic Plague and Adenoiditis are associated with LY75. The related pathways of LY75 include Dendritic Cells Developmental Lineage Pathway.

DEC-205 Protein (1)

    DEC-205 Antibody (4)

      DEC-205 cDNA Clone (2)

      NM_013825.3

      In expression vector

      In lentiviral vector

      DEC-205 Lysate (1)

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        DEC-205 分子背景

        LY75 (Lymphocyte Antigen 75) is a Protein Coding gene. It is broadly expressed in the lymph node, appendix, and other tissues. LY75 knockdown in SKOV3 cells resulted in predominant upregulation of functional pathways implicated in cell proliferation and metabolism, while pathways associated with cell signaling and adhesion, complement activation, and immune response were mostly suppressed. Moreover, LY75 suppression had an opposite effect on EOC cell lines with the epithelial phenotype (A2780s and OV2008), by directing epithelial-to-mesenchymal transition (EMT) associated with reduced capacity for in vivo EOC cell colonization, as similar/identical signaling pathways were reversely regulated, when compared to mesenchymal LY75 knockdown EOC cells. Diseases associated with LY75 include Pneumonic Plague and Adenoiditis.

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