DRD1 Antibodies, cDNA Clones Research Reagents

DRD1 (Dopamine Receptor D1, also known as DADR; DRD1A), located on 5q35.2, is a Protein Coding gene. This gene encodes the D1 subtype of the dopamine receptor. It belongs to the G-protein coupled receptor 1 family. This G-protein coupled receptor stimulates adenylyl cyclase and activates cyclic AMP-dependent protein kinases. D1 receptors regulate neuronal growth and development, mediate some behavioral responses, and modulate dopamine receptor D2-mediated events. DRD1 is thought to mediate some of the cognitive deficits in schizophrenia (SCZ).

DRD1 Antibody (1)

    DRD1 cDNA Clone (2)

    NM_000794.3

    In expression vector

    In lentiviral vector

    DRD1 分子背景

    The dopamine 1 receptor (DRD1) is thought to mediate some of the cognitive deficits in schizophrenia (SCZ), including impairment of working memory that relies on normal dorsolateral prefrontal cortex (DLPFC) function. DRD1 is a typical G protein-coupled receptor (GPCR) mainly expressed in the neurogenic area, with high constitutive activity. The receptor appears in the embryonic period before the formation of mature synaptic contacts, which indicates that the dopamine receptor and its constitutive activity play crucial roles in embryonic brain development. Cells expressing the DRD1 have significant functional roles in diverse physiological processes including locomotion and drug addiction. Neurotransmitter dopamine (DA) inhibits NLRP3 inflammasome activation via dopamine D1 receptor (DRD1). DRD1 signaling negatively regulates NLRP3 inflammasome via a second messenger cyclic adenosine monophosphate (cAMP).

    DRD1 参考文献

    • Yao F, et al. (2013) A tet-on system for drd1-expressing cells. PLoS One 8 (8): e72681.
    • Yan Y, et al. (2015) Dopamine controls systemic inflammation through inhibition of nlrp3 inflammasome. Cell 160 (1-2): 62-73.
    • Wang Q, et al. (2020) Constitutive activity of a g protein-coupled receptor, drd1, contributes to human cerebral organoid formation. Stem Cells 38 (5): 653-665.
    • Kaalund SS, et al. (2014) Contrasting changes in drd1 and drd2 splice variant expression in schizophrenia and affective disorders, and associations with snps in postmortem brain. Mol Psychiatry 19 (12): 1258-1266.

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