The dopamine 1 receptor (DRD1) is thought to mediate some of the cognitive deficits in schizophrenia (SCZ), including impairment of working memory that relies on normal dorsolateral prefrontal cortex (DLPFC) function. DRD1 is a typical G protein-coupled receptor (GPCR) mainly expressed in the neurogenic area, with high constitutive activity. The receptor appears in the embryonic period before the formation of mature synaptic contacts, which indicates that the dopamine receptor and its constitutive activity play crucial roles in embryonic brain development. Cells expressing the DRD1 have significant functional roles in diverse physiological processes including locomotion and drug addiction. Neurotransmitter dopamine (DA) inhibits NLRP3 inflammasome activation via dopamine D1 receptor (DRD1). DRD1 signaling negatively regulates NLRP3 inflammasome via a second messenger cyclic adenosine monophosphate (cAMP).