ELF3 Antibodies, cDNA Clones Research Reagents

All ELF3 reagents are produced in house and quality controlled, including 2 ELF3 Antibody, 33 ELF3 Gene, 2 ELF3 qPCR. All ELF3 reagents are ready to use.

ELF3 Antibody (2)

    ELF3 cDNA Clone (33)

    NM_004433.4

    克隆载体 cDNA 产品

    In expression vector

    In lentiviral vector

    NM_007921.3

    克隆载体 cDNA 产品

    In lentiviral vector

    NM_001024768.1

    克隆载体 cDNA 产品

    In lentiviral vector

    ELF3 qPCR Primer (2)

    ELF3 分子背景

    Chromosomal translocations leading to deregulated expression of ETS transcription factors are frequent in prostate tumors. ESE1/ELF3 was induced by interleukin (IL)-1beta through NF-kappaB and was a crucial mediator of the phenotypic and transcriptional changes induced by IL-1beta in prostate cancer cells. ESE1/ELF3 was overexpressed in human primary and metastatic tumors. E74-like factor 3 (ELF3) protein levels are increased in osteoarthritic (OA) cartilage, that ELF3 accounts for inflammatory cytokine-driven MMP13 gene expression, and that, upon induction by interleukin-1beta, ELF3 binds to the COL2A1 promoter and suppresses its activity in chondrocytes. ELF3 is a favorable prognostic marker for ovarian cancer. As a negative regulator of EMT, ELF3-modulated reversal of EMT may be a new effective modality in the treatment of ovarian cancer.

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