ENPP7 Proteins, Antibodies, cDNA Clones Research Reagents

All ENPP7 reagents are produced in house and quality controlled, including 5 ENPP7 Antibody, 26 ENPP7 Gene, 2 ENPP7 Lysate, 2 ENPP7 Protein, 2 ENPP7 qPCR. All ENPP7 reagents are ready to use.

ENPP7 Protein (2)

    ENPP7 Antibody (5)

      ENPP7 cDNA Clone (26)

      NM_178543.3

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_001030291.1

      克隆载体 cDNA 产品

      In lentiviral vector

      ENPP7 Lysate (2)

        ENPP7 分子背景

        Ectonucleotide pyrophosphatase / phosphodiesterase family member 7, also known as Alkaline sphingomyelin phosphodiesterase, Intestinal alkaline sphingomyelinase, Alk-Smase, ENPP7 and NPP-7, is a single-pass type I membrane protein which belongs to thenucleotide pyrophosphatase / phosphodiesterase family. ENPP7 / NPP-7 is expressed in the intestines and human bile. ENPP7 / NPP-7 is localized at the surface of the microvillar membrane in small intestine enterocytes, as well as in endosome-like structures and in Golgi complex. The main function of ENPP7 / NPP-7 is to convert the dietary sphingomyelin into ceramide, the sphingolipid messengers via hydrolyzation. ENPP7 / NPP-7 is also reported to exert a phospholipase C activity toward palmitoyl lyso-phosphocholine. The activity of this enzyme is inhibited in a dose dependent manner by ATP, imidazole, orthovanadate and zinc ion. Further, It has been shown in studies that decreased levels of ENPP7 / NPP-7 may be associated with human colon cancer.

        ENPP7 参考文献

        • Wu J. et al., 2005, Biochem. J. 386:153-60.
        • Wu J. et al., 2004, Carcinogenesis 25:1327-33.
        • Duan R.-D. et al., 2003, J. Lipid Res. 44:1241-50.
        • Duan R.-D. et al., 2003, J. Biol. Chem. 278:38528-36.

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