EpCAM Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

All EpCAM reagents are produced in house and quality controlled, including 21 EpCAM Antibody, 2 EpCAM ELISA, 40 EpCAM Gene, 4 EpCAM IP Kit, 8 EpCAM Lysate, 13 EpCAM Protein, 2 EpCAM qPCR. All EpCAM reagents are ready to use.

EpCAM Protein (13)

    EpCAM Antibody (21)

      EpCAM ELISA 试剂盒(即用型)& ELISA 抗体对套装(非即用型)(2)

      EpCAM cDNA Clone (40)

      NM_002354.2

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_008532.2

      克隆载体 cDNA 产品

      NM_138541.1

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_001040029.1

      克隆载体 cDNA 产品

      In lentiviral vector

      EpCAM qPCR Primer (2)

      EpCAM Lysate (8)

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        EpCAM 分子背景

        Epithelial Cell Adhesion Molecule (EpCAM), also known as GA733-2 antigen, is a type â…transmembrane glycoprotein composed of an extracellular domain with two EGF-Like repeats and a cystenin-rich region, a transmembrane domain and a cytoplasmic domain. It modulates cell adhesion and proliferation. Its overexpression has been detected in many epithelial tumours and has been associated with high stage, high grade and a worse survival in some tumour types. EpCAM has been shown to function as a calcium-independent homophilic cell adhesion molecule that does not exhibit any obvious relationship to the four known cell adhesion molecule superfamilies. However, recent insights have revealed that EpCAM participates in not only cell adhesion, but also in proliferation, migration and differentiation of cells. In addition, recent study revealed that EpCAM is the Wnt-beta-catenin signaling target gene and may be used to facilitate prognosis. It has oncogenic potential and is activated by release of its intracellular domain, which can signal into the cell nucleus by engagement of elements of the wnt pathway.

        EpCAM 参考文献

        • Brunner A, et al. (2008) EpCAM is predominantly expressed in high grade and advanced stage urothelial carcinoma of the bladder. J Clin Pathol. 61(3):307-10.
        • Trzpis M, et al. (2008) EpCAM in morphogenesis. Front Biosci. 13: 5050-5.
        • Munz M, et al. (2009) The emerging role of EpCAM in cancer and stem cell signaling. Cancer Res. 69(14): 5627-9.
        • Carpenter G, et al. (2009) EpCAM: another surface-to-nucleus missile. Cancer Cell. 15(3): 165-6.

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