ERCC6L Antibodies, cDNA Clones Research Reagents

ERCC6L (ERCC Excision Repair 6 Like, Spindle Assembly Checkpoint Helicase), located on human chromosome Xq13.1, encodes a member of the SWItch/Sucrose Non-Fermentable (SWI/SNF2) family of proteins, and contains a SNF2-like ATPase domain and a PICH family domain. ERCC6L is also known as PICH and RAD26L. The human ERCC6L gene encodes a 141103 Da protein containing 1250 amino acids. The ERCC6L protein is broadly expressed in lymph node, bone marrow and other tissues. ERCC6L is related to nucleic acid binding and helicase activity. CHD5 is an important paralog of ERCC6L gene. ERCC6L is associated with some diseases, such as Cavernous Hemangioma.

ERCC6L Antibody (1)

    ERCC6L cDNA Clone (3)


    In expression vector

    ERCC6L 分子背景

    A newly identified ERCC6-like gene in mice, ERCC6L, also known as polo-like kinase 1 (PLK1)-interacting checkpoint helicase, has been demonstrated to be a development-associated member of the SNF2 family. Excision repair cross-complementation group 6 like (ERCC6L) is highly expressed in a variety of human cancer types. The ERCC6L protein is assembled in the cytoplasm and then enters the cell nucleus to exert its function. It is strongly expressed in the mouse embryonic stage, particularly in embryonic brain, heart, kidney, liver and lung. ERCC6L silencing has been revealed to inhibit the proliferation of cancer cells, which suggests that ERCC6L may be an effective biomarker for cancer progression.

    ERCC6L 参考文献

    • Huang Y, et al. (2019) Loss of pich promotes chromosome instability and cell death in triple-negative breast cancer. Cell Death Dis 10 (6): 428.
    • Zhang G, et al. (2019) Ercc6l that is up-regulated in high grade of renal cell carcinoma enhances cell viability in vitro and promotes tumor growth in vivo potentially through modulating mapk signalling pathway. Cancer Gene Ther 26 (9-10): 323-333.

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