Factor D Proteins, Antibodies, cDNA Clones Research Reagents

All Factor D reagents are produced in house and quality controlled, including 11 Factor D Antibody, 18 Factor D Gene, 2 Factor D Lysate, 2 Factor D Protein, 2 Factor D qPCR. All Factor D reagents are ready to use.

Factor D Protein (2)

    Factor D Antibody (11)

      Factor D cDNA Clone (18)

      NM_001928.2

      In expression vector

      In lentiviral vector

      NM_001291915.1

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_001077642.1

      克隆载体 cDNA 产品

      In lentiviral vector

      Factor D Lysate (2)

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        Factor D 分子背景

        Complement factor D, also known as Adipsin, C3 convertase activator, Properdin factor D and CFD is a secreted protein which belongs to thepeptidase S1 family. CFD / Adipsin contains onepeptidase S1 domain. Complement factor D ( CFD / Adipsin ) is a component of the alternative complement pathway best known for its role in humoral suppression of infectious agents. Complement factor D ( CFD / Adipsin ) has a high level of expression in fat, suggesting a role for adipose tissue in immune system biology. This protein is also a serine protease that is secreted by adipocytes into the bloodstream. Complement factor D ( CFD / Adipsin ) cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway. Complement factor D ( CFD / Adipsin ) is a serine protease that stimulates glucose transport for triglyceride accumulation in fats cells and inhibits lipolysis. Defects in CFD / Adipsin are the cause of complement factor D deficiency (CFD deficiency) which predisposes to invasive meningococcal disease.

        Factor D 参考文献

        • Volanakis JE, et al.,1996, Protein Sci. 5 (4): 553-64.
        • Searfoss,G.H et al., 2003, J Biol Chem. 278 (46):46107-16.
        • Ukkola,O. et al., 2003, Eur J Clin Nutr. 57 (9):1073-8.
        • Ronti T, et al., 2006, Clin. Endocrinol. (Oxf) 64 (4): 355-65.

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