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Factor XI (蛋白 | 抗体 | cDNA 克隆 | ELISA 试剂盒)

All Factor XI reagents are produced in house and quality controlled, including 9 Factor XI Antibody, 28 Factor XI Gene, 1 Factor XI Lysate, 1 Factor XI Protein, 2 Factor XI qPCR. All Factor XI reagents are ready to use.

Factor XI Protein (1)

    Factor XI Antibody (9)

      Factor XI cDNA Clone (28)

      NM_000128.3

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_028066.1

      克隆载体 cDNA 产品

      In lentiviral vector

      XM_006253144.2

      克隆载体 cDNA 产品

      In lentiviral vector

      Factor XI Lysate (1)

        Factor XI 分子背景

        Factor XI (plasma thromboplastin antecedent) is a plasma glycoprotein, and a zymogen acting as a serine protease which participates in blood coagulation as a catalyst in the conversion of factor IX to factor IXa in the presence of calcium ions. It is an unusual dimeric protease, with structural features that distinguish it from vitamin K-dependent coagulation proteases. The factor XI is synthesized in the liver as a single polypeptide chain with a molecular weight estimated between 125 ~16 kDa and then is processed into a disulfide-bond linked homodimer. FXI is a homodimer, with each subunit containing four apple domains and a protease domain. The apple domains form a disk structure with binding sites for platelets, high molecular weight kininogen, and the substrate factor IX (FIX). FXI is converted to the active protease FXIa by cleavage of the Arg369-Ile37 bond on each subunit. After the activation reaction, Factor XIa is composed of two heavy and two light chains held together by three disulfide bonds. The heavy chains are derived from the amino termini of the zymogen and responsible for the binding of factor XI to high molecular weight kininogen and for the activation of factor IX, while the light chain contains the catalytic portion of the enzyme and is homologous to the trypsin family of serine proteases. FXI deficiency is a disorder characterized by a mild or no bleeding tendency. Severe FXI deficiency is an injury-related bleeding disorder common in Ashkenazi Jews and rare worldwide.

        Factor XI 参考文献

        • Gailani D, et al. (2009) Structural and functional features of factor XI. J Thromb Haemost. 7 Suppl 1: 75-8.
        • Duga S, et al. (2009) Factor XI Deficiency. Semin Thromb Hemost. 35(4): 416-25.
        • Emsley J, et al. (2010) Structure and function of factor XI. Blood. 115(13): 2569-77.

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