FAM123A Antibodies, cDNA Clones Research Reagents

AMER2 (APC Membrane Recruitment Protein 2) is a protein coding gene located on human chromosome 13q12.13. AMER2 is also known as FAM123A. The FAM123A protein is restrictedly expressed toward brain. FAM123A is a negative regulator of the canonical Wnt signaling pathway involved in neuroectodermal patterning. AMER2 is related to phosphatidylinositol-4,5-bisphosphate binding. AMER1 is an important paralog of AMER2 gene. AMER2 is associated with Osteopathia Striata With Cranial Sclerosis.

FAM123A Antibody (1)

    FAM123A cDNA Clone (1)


    In expression vector


    FAM123A 分子背景

    Amer2 (APC membrane recruitment 2; FAM123A) is a direct interaction partner of adenomatous polyposis coli (APC), related to the tumor suppressor Amer1/WTX. FAM123A interacts with APC via two domains that bind the Armadillo repeats of APC. These domains are conserved in the related proteins Amer1/WTX (Wilms tumor gene on the X-chromosome; FAM123B), which acts as a negative regulator of Wnt signaling, and Amer3 (FAM123C). Amer1 is mutated in Wilms tumors and in the inherited disease osteopathia striata congenita with cranial sclerosis. Amer2 negatively regulates Wnt signaling probably by interfering with β-catenin.

    FAM123A 参考文献

    • Pfister AS, et al. (2012) Amer2 protein is a novel negative regulator of wnt/β-catenin signaling involved in neuroectodermal patterning. J Biol Chem 287 (3): 1734-1741.
    • Pfister AS, et al. (2012) Amer2 protein interacts with eb1 protein and adenomatous polyposis coli (apc) and controls microtubule stability and cell migration. J Biol Chem 287 (42): 35333-35340.
    • Boutet A, et al. (2010) The wtx/amer1 gene family: Evolution, signature and function. BMC Evol Biol 10 280.

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