FANCA Proteins, cDNA Clones Research Reagents

All FANCA reagents are produced in house and quality controlled, including 16 FANCA Gene, 1 FANCA Lysate, 1 FANCA Protein, 1 FANCA qPCR. All FANCA reagents are ready to use.

FANCA Protein (1)

    FANCA cDNA Clone (16)

    NM_000135.2

    克隆载体 cDNA 产品

    In lentiviral vector

    BC008979

    In lentiviral vector

    FANCA qPCR Primer (1)

    FANCA Lysate (1)

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      FANCA 分子背景

      FANCA is one of the six known Fanconi anemia gene products (FANCA, FANCC, FANCD2, FANCE, FANCF, and FANCG proteins). Fanconi anemia (FA) is a genetic disorder predisposing to aplastic anemia and cancer characterized by hypersensitivity to DNA-damaging agents and oxidative stress. FANCA associates with the IκB kinase (IKK) signalsome via interaction with IKK2. Components of the FANCA complex undergo rapid, stimulus-dependent changes in phosphorylation, which are blocked by kinase-inactive IKK2.

      FANCA 参考文献

      • Otsuki T, et al. (2002) Fanconi anemia protein complex is a novel target of the IKK signalsome. J Cell Biochem. 86 (4): 613-23.
      • Taniguchi T, et al. (2002) The Fanconi anemia protein, FANCE, promotes the nuclear accumulation of FANCC. Blood. 100 (7): 2457-62.
      • Garcia-Higuera I, et al. (1999) Fanconi anemia proteins FANCA, FANCC, and FANCG / XRCC9 interact in a functional nuclear complex. Mol Cell Biol. 19 (7): 4866-73.

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