FANCA Proteins, cDNA Clones Research Reagents

All FANCA reagents are produced in house and quality controlled, including 16 FANCA Gene, 1 FANCA Lysate, 1 FANCA Protein, 1 FANCA qPCR. All FANCA reagents are ready to use.

FANCA Protein (1)

    FANCA cDNA Clone (16)


    克隆载体 cDNA 产品

    In lentiviral vector


    In lentiviral vector

    FANCA qPCR Primer (1)

    FANCA Lysate (1)


      FANCA 分子背景

      FANCA is one of the six known Fanconi anemia gene products (FANCA, FANCC, FANCD2, FANCE, FANCF, and FANCG proteins). Fanconi anemia (FA) is a genetic disorder predisposing to aplastic anemia and cancer characterized by hypersensitivity to DNA-damaging agents and oxidative stress. FANCA associates with the IκB kinase (IKK) signalsome via interaction with IKK2. Components of the FANCA complex undergo rapid, stimulus-dependent changes in phosphorylation, which are blocked by kinase-inactive IKK2.

      FANCA 参考文献

      • Otsuki T, et al. (2002) Fanconi anemia protein complex is a novel target of the IKK signalsome. J Cell Biochem. 86 (4): 613-23.
      • Taniguchi T, et al. (2002) The Fanconi anemia protein, FANCE, promotes the nuclear accumulation of FANCC. Blood. 100 (7): 2457-62.
      • Garcia-Higuera I, et al. (1999) Fanconi anemia proteins FANCA, FANCC, and FANCG / XRCC9 interact in a functional nuclear complex. Mol Cell Biol. 19 (7): 4866-73.

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