FGF14 Proteins, Antibodies, cDNA Clones Research Reagents

All FGF14 reagents are produced in house and quality controlled, including 3 FGF14 Antibody, 75 FGF14 Gene, 2 FGF14 Protein, 2 FGF14 qPCR. All FGF14 reagents are ready to use.

FGF14 Protein (2)

    FGF14 Antibody (3)

      FGF14 cDNA Clone (75)

      NM_004115.3

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_010201.4

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_207667.3

      克隆载体 cDNA 产品

      In lentiviral vector

      XM_001093573.2

      克隆载体 cDNA 产品

      In lentiviral vector

      XM_003433069.1

      克隆载体 cDNA 产品

      In lentiviral vector

      FGF14 分子背景

      FGF14 is a member of the fibroblast growth factor (FGF) family. Members of this family possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF14 is probably involved in nervous system development and function. Defects in FGF14 are the cause of spinocerebellar ataxia type 27 (SCA27). It is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA27 is an autosomal dominant cerebellar ataxia. It is a slowly progressive disorder, with onset in late-childhood to early adulthood, characterized by ataxia with tremor, orofacial dyskinesia, psychiatric symptoms and cognitive deficits.

      FGF14 参考文献

      • Wang Q, et al. (2002) Ataxia and paroxysmal dyskinesia in mice lacking axonally transported FGF14. Neuron. 35 (1): 25-38.
      • Zhao Y, et al. (2007) Genetic analysis of SCA 27 in ataxia and childhood onset postural tremor. Am J Med Genet. 144B (3): 395-6.
      • Lou JY, et al. (2005) Fibroblast growth factor 14 is an intracellular modulator of voltage-gated sodium channels. J Physiol. 569 (1): 179-93.

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