FGL1被鉴定为抑制性受体LAG-3的主要配体,其阻断可以增强抗肿瘤T细胞应答。
• FGL1是LAG-3的主要配体,可介导T细胞抑制
• FGL1通常由肝脏以低水平释放,但可由癌细胞高水平释放
• 阻断FGL1-LAG-3相互作用可增强抗肿瘤免疫力
货号 | 产品描述 | 种属 | 标签 | 表达宿主 | 规格 |
13484-H08B | 重组FGL1蛋白 | 人 | His | Baculovirus-Insect Cells | 20µg / 100µg / 定制规格 |
货号 | 产品描述 | 种属 | 标签 | 表达宿主 | 规格 |
16498-HNAH-B | Biotinylated LAG3 Protein | Human | Native | HEK293 Cells | 20µg / custom size |
货号 | 种属 | 标签 | 表达宿主 | 规格 |
16498-HNAH | Human | Native | HEK293 Cells | 50µg / 200µg |
16498-H08H | Human | His tag | HEK293 Cells | 50µg / 200µg |
16498-H05H | Human | Fc tag | HEK293 Cells | 50µg / 200µg |
16498-H02H | Human | Fc tag | HEK293 Cells | 50µg / 200µg |
53069-M02H | Mouse | Fc tag | HEK293 Cells | 50µg / 200µg |
53069-M02H4 | Mouse | Fc tag | HEK293 Cells | 50µg / 200µg |
53069-M08H | Mouse | His tag | HEK293 Cells | 50µg / 200µg |
53069-M08H3 | Mouse | His tag | HEK293 Cells | 50µg / 200µg |
80367-R08H | Rat | His tag | HEK293 Cells | 50µg / 200µg |
90841-C08H | Cynomolgus | His tag | HEK293 Cells | 50µg / 200µg |
货号 | 产品描述 | 应用 | 稀释度 | 特异性 |
53069-T16 | Anti-LAG3 Antibody, Rabbit Pab | ELISA | 1:5000-1:10000 | Mouse LAG3 |
• Wang et al.Fibrinogen-like Protein 1 Is a Major Immune Inhibitory Ligand of LAG-3,2019, Cell 176, 1–14
• Nagdas SK, Winfrey VP, Olson GE.Two fibrinogen-like proteins, FGL1 and FGL2 are disulfide-linked subunits of oligomers that specifically bind nonviable spermatozoa.Int J Biochem Cell Biol. 2016 Nov;80:163-172
• Nayeb-Hashemi H, Desai A,et al.Targeted disruption of fibrinogen like protein-1 accelerates hepatocellular carcinoma development.Biochem Biophys Res Commun. 2015 Sep 18;465(2):167-73.