FOLR1 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

All FOLR1 reagents are produced in house and quality controlled, including 8 FOLR1 Antibody, 1 FOLR1 ELISA, 28 FOLR1 Gene, 1 FOLR1 IP Kit, 7 FOLR1 Lysate, 7 FOLR1 Protein, 2 FOLR1 qPCR. All FOLR1 reagents are ready to use.

FOLR1 Protein (7)

FOLR1 Antibody (8)

    FOLR1 ELISA 试剂盒(即用型)& ELISA 抗体对套装(非即用型)(1)

    FOLR1 cDNA Clone (28)

    NM_016725.1

    克隆载体 cDNA 产品

    In lentiviral vector

    NM_008034.2

    克隆载体 cDNA 产品

    In lentiviral vector

    NM_133527.1

    克隆载体 cDNA 产品

    XM_005633554.2

    克隆载体 cDNA 产品

    FOLR1 Lysate (7)

      FOLR1 分子背景

      The protein encoded by FOLR1 gene is a member of the folate receptor family. Members of this gene family bind folic acid and its reduced derivatives, and transport 5-methyltetrahydrofolate into cells. This gene product is a secreted protein that either anchors to membranes via a glycosyl-phosphatidylinositol linkage or exists in a soluble form. Mutations in this gene have been associated with neurodegeneration due to cerebral folate transport deficiency. Due to the presence of two promoters, multiple transcription start sites, and alternative splicing, multiple transcript variants encoding the same protein have been found for this gene.
      Folate receptor α (FRα) is the most important subunit of Folate receptor and the alpha isoform has been shown to be selectively overexpressed in cancer types like breast and ovarian cancer compared to normal breast and ovarian epithelial cells. It was determined that Folate receptor α exhibits a limited expression on the apical surfaces of the epithelial cells of normal lung, breast, thyroid, parathyroid, and kidney tissues. For their uptake of folate, normal cells rely almost exclusively on the reduced folate carrier, whereas many carcinomas and myeloid leukemia cells overexpress a high-affinity FR on their surfaces, perhaps reflecting their increased need for folate to support rapid cell division.

      FOLR1 参考文献

      • Senol S, Ceyran AB, Aydin A, et al. Folate receptor α expression and significance in endometrioid endometrium carcinoma and endometrial hyperplasia. International Journal of Clinical and Experimental Pathology. 2015;8(5):5633-5641.

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