Galectin-1 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

All Galectin-1 reagents are produced in house and quality controlled, including 14 Galectin-1 Antibody, 2 Galectin-1 ELISA, 52 Galectin-1 Gene, 3 Galectin-1 IP Kit, 3 Galectin-1 Protein, 3 Galectin-1 qPCR. All Galectin-1 reagents are ready to use.

Galectin-1 Protein (3)

    Galectin-1 Antibody (14)

      Galectin-1 ELISA 试剂盒(即用型)& ELISA 抗体对套装(非即用型)(2)

      Galectin-1 cDNA Clone (52)

      NM_002305.3

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_008495.2

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_019904.1

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_001168627.1

      克隆载体 cDNA 产品

      In lentiviral vector

      Galectin-1 分子背景

      Galectin-1 (Gal-1, GAL1), is a member of the galectins, a family of animal lectins ranging from Caenorhabditis elegans to humans, which is defined by their affinity for beta-galactosides and by significant sequence similarity in the carbohydrate-binding site. It is a homodimer with a subunit molecular mass of 14.5 kDa, which contains six cysteine residues per subunit. The cysteine residues should be in a free state in order to maintain a molecular structure that is capable of showing lectin activity. This endogenous lectin widely expressed at sites of inflammation and tumour growth, has been postulated as an attractive immunosuppressive agent to restore immune cell tolerance and homeostasis in autoimmune and inflammatory settings. On the other hand, galectin-1 contributes to different steps of tumour progression including cell adhesion, migration and tumour-immune escape, suggesting that blockade of galectin-1 might result in therapeutic benefits in cancer. Several potential glycoprotein ligands for galectin-1 have been identified, including lysosome-associated membrane glycoproteins and fibronectin, laminin, as well as T-cell glycoproteins CD43 and CD45. Evidence points to Gal-1 and its ligands as one of the master regulators of such immune responses as T-cell homeostasis and survival, T-cell immune disorders, inflammation and allergies as well as host-pathogen interactions.

      Galectin-1 参考文献

      • Gaudet AD, et al. (2005) Expression and functions of galectin-1 in sensory and motoneurons. Curr Drug Targets. 6(4): 419-25.
      • Kadoya T, et al. (2006) Structural and functional studies of galectin-1: a novel axonal regeneration-promoting activity for oxidized galectin-1. Curr Drug Targets. 6(4): 375-83.
      • Camby I, et al. (2006) Galectin-1: a small protein with major functions. Glycobiology. 16(11): 137R-157R.
      • Salatino M, et al. (2008) Galectin-1 as a potential therapeutic target in autoimmune disorders and cancer. Expert Opin Biol Ther. 8(1): 45-57.

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