GAP43 Proteins, Antibodies, cDNA Clones Research Reagents

All GAP43 reagents are produced in house and quality controlled, including 1 GAP43 Antibody, 18 GAP43 Gene, 1 GAP43 IP Kit, 1 GAP43 Lysate, 1 GAP43 Protein, 1 GAP43 qPCR. All GAP43 reagents are ready to use.

GAP43 Protein (1)

    GAP43 Antibody (1)

      GAP43 cDNA Clone (18)

      BC007936

      In expression vector

      In lentiviral vector

      NM_008083.2
      NM_017195.3

      克隆载体 cDNA 产品

      In lentiviral vector

      GAP43 qPCR Primer (1)

      GAP43 Lysate (1)

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        GAP43 分子背景

        Neuromodulin, also known as Axonal membrane protein GAP-43, Growth-associated protein 43, Neural phosphoprotein B-5, pp46 and GAP43, is a cell membrane protein which belongs to theneuromodulin family. Neuromodulin / GAP43 contains oneIQ domain. Neuromodulin / GAP43 is associated with nerve growth. It is a major component of the motile "growth cones" that form the tips of elongating axons. Neuromodulin / GAP43 is involved in neurite outgrowth, a crucial process for the differentiation of neurons. The sudden infant death syndrome (SIDS) is the main cause of postneonatal infant death and its cause is still unknown. Neuromodulin / GAP43 is a marker of synaptic plasticity and is critical for normal development of the serotonergic innervation. Neuromodulin / GAP43 is a major cortical cytoskeleton-associated and calmodulin binding protein that is widely and abundantly expressed during development, maintained in selected brain structures in the adult, and reinduced during nerve regeneration. CAP23 and GAP43 are functionally related intrinsic determinants of anatomical plasticity. These proteins function by locally promoting subplasmalemmal actin cytoskeleton accumulation.

        GAP43 参考文献

        • Frey,D. et al., 2000, J Cell Biol. 149 (7):1443-54.
        • Caprini,M. et al., 2003, EMBO J. 22 (12):3004-14.
        • Sawaguchi,T. et al., 2003, Early Hum Dev. 75 Suppl :S139-46.
        • Kowara,R. et al., 2007, Biochem Biophys Res Commun  363 (1):190-3.

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