GCNF/NR6A1 Antibodies, cDNA Clones Research Reagents

NR6A1 (Nuclear Receptor Subfamily 6 Group A Member 1) is a protein coding gene located on human chromosome 9q33.3. NR6A1 is also known as RTR, GCNF, NR61, hRTR, CT150, GCNF1 and hGCNF. The human NR6A1 gene encodes a 54383 Da protein containing 480 amino acids. The NR6A1 protein is biasedly expressed in testis, thyroid and other tissues. Among its related pathways are Transcriptional regulation of pluripotent stem cells and Gene Expression. NR6A1 is related to DNA-binding transcription factor activity and sequence-specific DNA binding. NR6A1 is associated with some diseases, including Embryonal Carcinoma and Teratocarcinoma.

GCNF/NR6A1 Antibody (1)

    GCNF/NR6A1 cDNA Clone (1)

    NM_001278546.1

    In expression vector

    GCNF/NR6A1 分子背景

    NR6A1/CT150, as an orphan receptor, is a novel member of the cancer-testis (CT) antigen family. Nuclear receptor subfamily 6, group A, member 1 (NR6A1) is involved in regulating embryonic stem cell differentiation, reproduction, neuronal differentiation. Down regulation of NR6A1 could reverse epithelial-to-mesenchymal transition (EMT) process in DU145 and PC3 cell lines, and the overexpression could enhance EMT process in 22RV1 cell line. NR6A1 played a prominent role in migration and invasion of PCa cells, and it is indicated that NR6A1 may act as a novel marker for biochemical recurrence after radical prostatectomy.

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