GITR Proteins, Antibodies, cDNA Clones Research Reagents

All GITR reagents are produced in house and quality controlled, including 4 GITR Antibody, 29 GITR Gene, 4 GITR Lysate, 8 GITR Protein, 2 GITR qPCR. All GITR reagents are ready to use.

GITR Protein (8)

    GITR Antibody (4)

      GITR cDNA Clone (29)

      NM_004195.2

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_009400.2

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_001024349.1

      克隆载体 cDNA 产品

      In lentiviral vector

      XM_005545123.2

      克隆载体 cDNA 产品

      GITR qPCR Primer (2)

      GITR Lysate (4)

        GITR 分子背景

        GITR, also known as TNFRSF18(CD357), belongs to the tumor necrosis factor receptor (TNF-R) superfamily. It is the receptor for TNFSF18. GITR plays a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. GITR may be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. GITR and its ligand are important costimulatory molecules in the pathogenesis of autoimmune diseases. It also mediates NF-kappa-B activation via the TRAF2/NIK pathway.

        GITR 参考文献

        • Kwon B, et al. (1999) Identification of a novel activation-inducible protein of the tumor necrosis factor receptor superfamily and its ligand. J Biol Chem. 274(10):6056-61.
        • Nocentini G, et al. (1997) A new member of the tumor necrosis factor/nerve growth factor receptor family inhibits T cell receptor-induced apoptosis. Proc Natl Acad Sci. 94(12): 6216-21.
        • Baltz KM, et al. (2007) Cancer immunoediting by GITR (glucocorticoid-induced TNF-related protein) ligand in humans: NK cell/tumor cell interactions. FASEB J. 21(10):2442-54.

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