Granulin Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

All Granulin reagents are produced in house and quality controlled, including 10 Granulin Antibody, 4 Granulin ELISA, 28 Granulin Gene, 2 Granulin Lysate, 2 Granulin Protein, 2 Granulin qPCR. All Granulin reagents are ready to use.

Granulin Protein (2)

    Granulin Antibody (10)

      Granulin ELISA 试剂盒(即用型)& ELISA 抗体对套装(非即用型)(4)

      Granulin cDNA Clone (28)

      NM_002087.2

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_008175.4

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_017113.2

      克隆载体 cDNA 产品

      In lentiviral vector

      Granulin Lysate (2)

        更多受客户欢迎的产品

        Granulin 分子背景

        Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling. Granulin-4 promotes proliferation of the epithelial cell line A431 in culture while granulin-3 acts as an antagonist to granulin-4, inhibiting the growth. Granulin expression inhibited Tat transactivation, and tethering experiments showed that this effect was due, at least in part, to a direct action on cyclin T1 in the absence of Tat.

        Granulin 参考文献

        • Hoque M, et al. (2003) The growth factor granulin interacts with cyclin T1 and modulates P-TEFb-dependent transcription. Mol Cell Biol. 23(5): 1688-702.
        • Bateman A, et al. (1990) Granulins, a novel class of peptide from leukocytes. Biochem Biophys Res Commun. 173(3): 1161-8.
        • Trinh DP, et al. (1999) Epithelin/granulin growth factors: extracellular cofactors for HIV-1 and HIV-2 Tat proteins. Biochem Biophys Res Commun. 256(2): 299-306.

        Note: Flag® is a registered trademark of Sigma Aldrich Biotechnology LP. It is used here for informational purposes only.