Gremlin 1/GREM1 Proteins, Antibodies, cDNA Clones Research Reagents

GREM1 (Gremlin 1, DAN Family BMP Antagonist, also known as DRM; HMPS; MPSH; PIG2; CRAC1; CRCS4; DAND2; HMPS1; IHG-2; DUP15q; C15DUPq; GREMLIN; CKTSF1B1), located on 15q13.3, is a Protein Coding gene. The gene produces a 20697 Da protein composed of 184 amino acids. GREM1 is a cysteine knot-secreted protein and acts as an inhibitor in the TGF beta signaling pathway. It belongs to the DAN family and is highly expressed in the small intestine, fetal brain, and colon. Diseases such as Polyposis Syndrome, Hereditary Mixed, 1, and Hereditary Mixed Polyposis Syndrome are associated with GREM1.

Gremlin 1/GREM1 Protein (1)

    Gremlin 1/GREM1 Antibody (2)

      Gremlin 1/GREM1 cDNA Clone (26)

      NM_013372.5

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_011824.3

      克隆载体 cDNA 产品

      In lentiviral vector

      Gremlin 1/GREM1 Lysate (1)

        Gremlin 1/GREM1 分子背景

        GREM1 belongs to the DAN family. It contains 1 CTCK (C-terminal cystine knot-like) domain. GREM1 is a cysteine knot-secreted protein and acts as an inhibitor in the TGF beta signaling pathway. It inhibits BMP-2, -4, and -7. Inhibition by Grem 1 of BMPs in mice allows the expression of fibroblast growth factors (FGFs) 4 and 8 and Sonic hedgehog (Shh) which are necessary for proper limb development. It interacts with SLIT1 and SLIT2 in a glycosylation-dependent manner. As a cytokine, GREM1 may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. It down-regulates the BMP4 signaling in a dose-dependent manner. It also acts as an inhibitor of monocyte chemotaxis. GREM1 is highly expressed in the small intestine, fetal brain, and colon.

        Gremlin 1/GREM1 参考文献

        • Dimitrov BI, et al. (2010) Genomic rearrangements of the GREM1-FMN1 locus cause oligosyndactyly, radio-ulnar synostosis, hearing loss, renal defects syndrome and Cenani--Lenz-like non-syndromic oligosyndactyly. J Med Genet. 47(8):569-74.
        • Heron M, et al. (2011) Genetic variation in GREM1 is a risk factor for fibrosis in pulmonary sarcoidosis. Tissue Antigens. 77(2):112-7.
        • van Vlodrop IJ, et al. (2010) Prognostic significance of Gremlin1 (GREM1) promoter CpG island hypermethylation in clear cell renal cell carcinoma. Am J Pathol. 176(2):575-84.

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