HDAC1 (Histone Deacetylase 1) is a Protein Coding gene. Histone Deacetylase 1 protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. HDAC1 is a ubiquitous deacetylase enzyme responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3, and H4). Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis. HDAC1 is widely expressed in the lymph node, colon, and other tissues. Diseases associated with HDAC1 include Atrichia With Papular Lesions and Retinoblastoma.