HDAC8 Proteins, Antibodies, cDNA Clones Research Reagents

HDAC8 (Histone Deacetylase 8, also known as HD8; WTS; RPD3; CDA07; CDLS5; KDAC8; MRXS6; HDACL1), located on Xq13.1, is a Protein Coding gene. The gene produces a 41758 Da protein composed of 377 amino acids. HDAC8 is a class I HDAC. Sequence analysis predicted that the HDAC8 protein contains the 9 conserved HDAC blocks that are presumably important for catalytic function. Diseases such as Cornelia De Lange Syndrome 5 and Cornelia De Lange Syndrome 1 are associated with HDAC8. The related pathways of HDAC8 include Signaling by GPCR and Chromatin organization.

HDAC8 Protein (2)

    HDAC8 Antibody (1)

      HDAC8 cDNA Clone (30)

      NM_018486.1

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_027382.3

      克隆载体 cDNA 产品

      In lentiviral vector

      HDAC8 Lysate (2)

        HDAC8 分子背景

        Histone deacetylase 8, also known as HDAC8 and HDACL1, is a nucleus and cytoplasm protein that belongs to the histone deacetylase family and HD type 1 subfamily. Histone deacetylases (HDACs) are a growing family of enzymes implicated in transcriptional regulation by affecting the acetylation state of core histones in the nucleus of cells. HDAC8 / HDACL1 is weakly expressed in most tissues. It is expressed at a higher level in the heart, brain, kidney, and pancreas and also in the liver, lung, placenta, prostate, and kidney. HDAC8 / HDACL1 is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones ( H2A, H2B, H3, and H4 ). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression, and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. HDAC8 / HDACL1 may play a role in smooth muscle cell contractility. HDAC8 / HDACL1 may be a potential drug target for neuroblastoma differentiation therapy using selective inhibitors, avoiding unspecific side effects.

        HDAC8 参考文献

        • Buggy JJ. et al.,2000, Biochem J. 350 (1): 199-205.
        • Krennhrubec K. et al., 2007, Bioorg Med Chem Lett. 17 (10): 2874-8.
        • Oehme I. et al., 2009, Expert Opin Investig Drugs.18 (11): 1605-17.

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