HE4 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

All HE4 reagents are produced in house and quality controlled, including 10 HE4 Antibody, 2 HE4 ELISA, 41 HE4 Gene, 3 HE4 Lysate, 3 HE4 Protein, 2 HE4 qPCR. All HE4 reagents are ready to use.

HE4 Protein (3)

    HE4 Antibody (10)

      HE4 ELISA 试剂盒(即用型)& ELISA 抗体对套装(非即用型)(2)

      HE4 cDNA Clone (41)

      NM_006103.3

      In expression vector

      In lentiviral vector

      NM_026323.2

      克隆载体 cDNA 产品

      In lentiviral vector

      AJ515241.1

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_001003241.1

      克隆载体 cDNA 产品

      In lentiviral vector

      HE4 qPCR Primer (2)

      HE4 Lysate (3)

        HE4 分子背景

        WAP four-disulfide core domain protein 2, also known as Epididymal secretory protein E4, Major epididymis-specific protein E4, Putative protease inhibitor WAP5, WFDC2 and HE4, is a secreted protein which contains twoWAP domains. WFDC2 / HE4 is a member of a family of stable 4-disulfide core proteins that are secreted at high levels. It is expressed in a number of normal tissues, including male reproductive system, regions of the respiratory tract and nasopharynx. It is highly expressed in a number of tumors cells lines, such ovarian, colon, breast, lung and renal cells lines. Initially described as being exclusively transcribed in the epididymis. WFDC2 may be a component of the innate immune defences of the lung, nasal and oral cavities and suggest that WFDC2 functions in concert with related WAP domain containing proteins in epithelial host defence. WFDC2 re-expression in lung carcinomas may prove to be associated with tumour type and should be studied in further detail. Mammary gland expression of tammar WFDC2 during the course of lactation showed WFDC2 was elevated during pregnancy, reduced in early lactation and absent in mid-late lactation. WFDC2 / HE4 can undergo a complex series of alternative splicing events that can potentially yield five distinct WAP domain containing protein isoforms.

        HE4 参考文献

        • Bingle,L. et al., 2002, Oncogene. 21 (17):2768-73.
        • Hellström,I. et al., 2003, Cancer Res. 63 (13):3695-700.
        • Bingle,L. et al., 2006, Respir Res. 7 : 61.
        • Galgano,M.T. et al., 2006, Mod Pathol.19 (6):847-53.
        • Sharp,J.A. et al., 2007, Evol Dev. 9 (4): 378-92.

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