ICAM-1 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

ICAM1 (Intercellular Adhesion Molecule 1, also known as BB2; CD54; P3.58), located on 19p13.2, is a Protein Coding gene. The gene produces a 57825 Da protein composed of 532 amino acids. ICAM1 is critical for the firm arrest and transmigration of leukocytes out of blood vessels and into tissues. ICAM1 is an inducible glycoprotein of the immunoglobulin (Ig) superfamily that contains 5 distinct Ig-like domains, a transmembrane domain, and a short cytoplasmic tail. Diseases such as Malaria and Hepatocellular Carcinoma are associated with ICAM1.

ICAM-1 Protein (9)

    ICAM-1 Antibody (31)

      ICAM-1 ELISA 试剂盒(即用型)& ELISA 抗体对套装(非即用型)(4)

      ICAM-1 cDNA Clone (52)

      NM_000201.2

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_010493.2

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_012967.1

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_001047135.1

      克隆载体 cDNA 产品

      In lentiviral vector

      ICAM-1 Lysate (9)

        ICAM-1 分子背景

        Intercellular adhesion molecule-1 (ICAM-1, or CD54) is a 90 kDa member of the immunoglobulin (Ig) superfamily and is critical for the firm arrest and transmigration of leukocytes out of blood vessels and into tissues. ICAM-1 is constitutively present on endothelial cells, but its expression is increased by proinflammatory cytokines. The endothelial expression of ICAM-1 is increased in atherosclerotic and transplant-associated atherosclerotic tissue and animal models of atherosclerosis. Additionally, ICAM-1 has been implicated in the progression of autoimmune diseases. ICAM-1 is a ligand for LFA-1(integrin). When activated, leukocytes bind to endothelial cells via ICAM-1/LFA-1 interaction and then transmigrate into tissues. Presence with heavy glycosylation and other structural characteristics, ICAM-1 possesses binding sites for some immune-associated ligands and serves as the binding site for entry of the major group of human Rhinovirus (HRV) into various cell types. ICAM-1 also becomes known for its affinity for Plasmodium falciparum-infected erythrocytes (PFIE), providing more of a role in infectious disease. Previous studies have shown that ICAM-1 is involved in inflammatory reactions and that a defect in ICAM-1 gene inhibits allergic contact hypersensitivity.

        ICAM-1 参考文献

        • Xu H, et al. (2001) The role of ICAM-1 molecule in the migration of Langerhans cells in the skin and regional lymph node. Eur J Immunol. 31(10): 3085-93.
        • Terol MJ, et al. (2003) Soluble intercellular adhesion molecule-1 (s-ICAM-1/s-CD54) in diffuse large B-cell lymphoma: association with clinical characteristics and outcome. Ann Oncol. 14(3): 467-74.
        • Mendez MP, et al. (2006) Shedding of soluble ICAM-1 into the alveolar space in murine models of acute lung injury. Am J Physiol Lung Cell Mol Physiol. 290(5): L962-70.
        • Lawson C, et al. (2009) ICAM-1 signaling in endothelial cells. Pharmacol Rep. 61(1): 22-32.

        Note: Flag® is a registered trademark of Sigma Aldrich Biotechnology LP. It is used here for informational purposes only.