ICAM4 Proteins, cDNA Clones Research Reagents

ICAM4 (Intercellular Adhesion Molecule 4 (Landsteiner-Wiener Blood Group, also known as LW; CD242), located on 19p13.2, is a Protein Coding gene. The gene produces a 29265 Da protein composed of 271 amino acids. ICAM4 is a member of the immunoglobulin (Ig) gene superfamily and encodes the Landsteiner-Wiener (LW) blood group antigens. ICAM4 binds to the leukocyte adhesion LFA-1 protein. Diseases such as Blood Group System, Landsteiner-Wiener and Anemia, Congenital Dyserythropoietic, Type Iv are associated with ICAM4. The related pathways of ICAM4 include the Degradation of the extracellular matrix and the Autophagy Pathway.
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All ICAM4 Reagents

ICAM4 基本信息

ICAM4 Protein (1)

种属

    ICAM4 cDNA Clone (14)

    BC000046

    克隆载体 cDNA 产品

    In cloning vector

    In expression vector

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    C-GFPSpark® C-OFPSpark® C-DDK N-DDK C-His N-His C-HA N-HA C-Myc N-Myc

    In lentiviral vector

    C-GFPSpark®
    NM_023892.2

    In expression vector

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    ICAM4 qPCR Primer (1)

    ICAM4 Lysate (1)

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      ICAM4 分子背景

      ICAM4, also known as CD242, is a member of the immunoglobulin superfamily, the ICAM family. ICAM4 contains 2 Ig-like C2-type (immunoglobulin-like) domains. It is similar to the intercellular adhesion molecule (ICAM) protein family. ICAM4 binds to the leukocyte adhesion LFA-1 protein. ICAM4's first reported receptors were CD11a/CD18 and CD11b/CD18. ICAM4 functions as a ligand for the monocyte/macrophage-specific CD11c/CD18. Deletion of the individual immunoglobulin domains of ICAM4 demonstrated that both its domains contain binding sites for CD11c/CD18. CD11c/CD18 is expressed on macrophages in the spleen and bone marrow. Inhibition of erythrophagocytosis by anti-ICAM4 and anti-integrin antibodies suggests a role for these interactions in the removal of senescent red cells.

      ICAM4 参考文献

      • Gorst DW. et al., 1980, Vox Sanguinis. 38 (2): 99-105.
      • Vos GH. et al., 1973, Blood. 42 (3): 445-53.
      • Kim W. et al., 2011, Mol Cell. 44 (2): 325-40.
      • Daniels G. et al., 2002, Transfusion Medicine. 12 (5): 287-95.

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