IDO2 Proteins, Antibodies, cDNA Clones Research Reagents

IDO2 (Indoleamine 2,3-Dioxygenase 2, also known as INDOL1), located on 8p11.21, is a Protein Coding gene. The gene produces a 47075 Da protein composed of 420 amino acids. The enzyme encoded by the IDO2 gene metabolizes tryptophan in the kynurenine pathway. The human protein shares 72% identity with its 405-amino acid mouse homolog. IDO can be up-regulated via cytokines, and can thereby modulate the levels of tryptophan, which is vital for cell growth. The related pathways of IDO2 include Histidine, lysine, phenylalanine, tyrosine, proline, and tryptophan catabolism, and superpathway of tryptophan utilization.

IDO2 Protein (1)

    IDO2 Antibody (2)

      IDO2 cDNA Clone (30)

      NP_919270.2

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_145949.2

      克隆载体 cDNA 产品

      In lentiviral vector

      IDO2 qPCR Primer (1)

      IDO2 分子背景

      IDO2 belongs to the indoleamine 2,3-dioxygenase family. Indoleamine 2,3-dioxgyenase (IDO), is a cytosolic haem protein which, together with the hepatic enzyme tryptophan 2,3-dioxygenase, catalyzes the conversion of tryptophan and other indole derivatives to kynurenines. In addition to classic IDO (IDO1), a new variant, IDO2, has recently been described. IDO2 is expressed in the liver, small intestine, spleen, placenta, thymus, lung, brain, kidney, and colon. IDO is widely distributed in human tissues, its physiological role is not fully understood but is of great interest. IDO can be up-regulated via cytokines such as interferon-gamma, and can thereby modulate the levels of tryptophan, which is vital for cell growth. In humans and mice, the IDO1 and IDO2 genes are present tandemly in a tail-to-head arrangement on chromosome 8. In lower vertebrates such as zebrafish and toads, only a single IDO gene may be present that may be more IDO2-like in structure. This closer relationship to IDO2 suggests that IDO2 may be the ancestor of the better characterized IDO1 gene and that IDO1 might have been generated by gene duplication of IDO2 before the origin of tetrapods in mammalian evolutionary history. IDO2 catalyzes the first and rate-limiting step in the kynurenine pathway of tryptophan catabolism.

      IDO2 参考文献

      • Witkiewicz AK, et al. (2009) Genotyping and expression analysis of IDO2 in human pancreatic cancer: a novel, active target. J Am Coll Surg. 208 (5): 781-7.
      • Sorensen RB, et al. (2011) Spontaneous cytotoxic T-Cell reactivity against indoleamine 2,3-dioxygenase-2. Cancer Res. 71 (6): 2038-44.
      • Witkiewicz AK, et al. (2009) Genotyping and expression analysis of IDO2 in human pancreatic cancer: a novel, active target. J Am Coll Surg. 208 (5): 781-7.

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