IFI30 Proteins, Antibodies, cDNA Clones Research Reagents

IFI30 (IFI30 Lysosomal Thiol Reductase, also known as GILT; IP30; IP-30; IFI-30), located on 19p13.11, is a Protein Coding gene. The gene produces a 27964 Da protein composed of 250 amino acids. IFI30 is a lysosomal thiol reductase that can reduce protein disulfide bonds. GILT is essential for cross-presentation of a CD8+ T cell epitope of glycoprotein B from herpes simplex virus-1 (HSV-1) but not for its presentation by infected cells. Diseases such as Lassa Fever and Eunuchism are associated with IFI30. The related pathways of IFI30 include Interferon gamma signaling and the Innate Immune System.

IFI30 Protein (1)

    IFI30 Antibody (6)

      IFI30 cDNA Clone (26)

      NM_006332.4

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_023065.3

      克隆载体 cDNA 产品

      In lentiviral vector

      IFI30 qPCR Primer (1)

      IFI30 Lysate (1)

        IFI30 分子背景

        IFI30 belongs to the GILT family. This family includes the two characterized human gamma-interferon-inducible lysosomal thiol reductase (GILT) sequences: P13284 and Q9UL08. It also contains several other eukaryotic putative proteins with similarity to GILT. The aligned region contains three conserved cysteine residues. Besides, the two GILT sequences possess a C-X(2)-C motif that is shared by some of the other sequences in the family. This motif is thought to be associated with disulfide bond reduction. IFI30 is a lysosomal thiol reductase that can reduce protein disulfide bonds. It facilitates the generation of MHC class II-restricted epitopes from disulfide bond-containing antigens by the endocytic reduction of disulfide bonds. It also facilitates MHC class I-restricted recognition of exogenous antigens containing disulfide bonds by CD8+ T-cells or cross-presentation. IFI30 may facilitate the complete unfolding of proteins destined for lysosomal degradation and plays an important role in antigen processing.

        IFI30 参考文献

        • Haque MA, et al. (2002) Absence of gamma-Interferon-inducible Lysosomal Thiol Reductase in Melanomas Disrupts T Cell Recognition of Select Immunodominant Epitopes. J Exp Med. 195(10):1267-77.
        • Phan UT, et al. (2000) Gamma-interferon-inducible lysosomal thiol reductase (GILT). Maturation, activity, and mechanism of action. J Biol Chem. 275(34):25907-14.
        • Phan UT, et al. (2001) Multiple species express thiol oxidoreductases related to GILT. Immunogenetics. 53(4):342-6.

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