IFNGR2 Proteins, Antibodies, cDNA Clones Research Reagents

IFNGR2 (Interferon Gamma Receptor 2, also known as AF-1; IFGR2; IMD28; IFNGT1), located on 21q22.11, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, and chicken. The gene produces a 37806 Da protein composed of 337 amino acids. This gene (IFNGR2) encodes the non-ligand-binding beta chain of the gamma interferon receptor. Diseases such as Immunodeficiency 28 and Autosomal Dominant Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Ifngammar2 Deficiency are associated with IFNGR2. The related pathways of IFNGR2 include all-trans-retinoic Acid Mediated Apoptosis and Tuberculosis.

IFNGR2 Protein (1)

    IFNGR2 Antibody (3)

      IFNGR2 cDNA Clone (15)

      NM_005534.3

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_008338.3

      克隆载体 cDNA 产品

      In lentiviral vector

      IFNGR2 qPCR Primer (1)

      IFNGR2 Lysate (1)

        IFNGR2 分子背景

        Interferon-gamma receptor beta chain (IFNgammaR2), also known as IFNGR2, belongs to the type II cytokine receptor family, whose deficiency is a cause of autosomal recessive mendelian susceptibility to mycobacterial disease (MSMD), also known as familial disseminated atypical mycobacterial infection. This accessory factor is an integral part of the IFN-gamma signal transduction pathway and is likely to interact with GAF, JAK1, and/or JAK2. IFNGR2 is a component of the IFNgamma receptor complex along with the IFNgammaR alpha chain (IFNGR1) and is a new Bax suppressor. The C-terminal fragment (cytoplasmic domain) of IFNgammaR2 is expressed in human cancer cell lines of megakaryocytic cancer (DAMI), breast cancer (MDA-MD-468), and prostate cancer (PC3 cells). The Th1 cytokine IFNgamma, acting through its heterodimeric receptors, IFNgammaR1 and IFNgammaR2, in the induction/proliferation of Th1 cells, might suppress the Th2 responses that may underlie atopic asthma. IFNGR2 has always been seen as a key mechanism for shielding T lymphocytes from the antiproliferative effects of the IFNgamma-signal transducer and activator of the transcription 1 (STAT1) pathway.

        IFNGR2 参考文献

        • Gao PS, et al. (1999). Nonpathogenic common variants of IFNGR1 and IFNGR2 in association with total serum IgE levels. Biochem Biophys Res Commun. 263(2): 425-9.
        • Regis G, et al. (2006). IFNgammaR2 trafficking tunes IFNgamma-STAT1 signaling in T lymphocytes. Trends Immunol. 27(2):96-101.
        • Al-Muhsen S, et al. (2008). The genetic heterogeneity of mendelian susceptibility to mycobacterial diseases. J Allergy Clin Immunol. 122 (6): 1043-51.
        • Gomez JA, et al. (2009). The C-terminus of interferon gamma receptor beta chain (IFNgammaR2) has antiapoptotic activity as a Bax inhibitor. Cancer Biol Ther. 8(18): 1771-86.

        Note: Flag® is a registered trademark of Sigma Aldrich Biotechnology LP. It is used here for informational purposes only.