IGFBP7 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

IGFBP7 (Insulin-Like Growth Factor Binding Protein 7, also known as AGM; PSF; TAF; FSTL2; IBP-7; MAC25; IGFBP-7; RAMSVPS; IGFBP-7v; IGFBPRP1), located on 4q12, is a Protein Coding gene. The gene produces a 29130 Da protein composed of 282 amino acids. IGFBP7 plays a role in growth-regulatory pathways abrogated in meningiomas and breast carcinomas. IGFBP7 could inhibit cell growth, decrease soft agar colony formation activity, and induce apoptosis in RKO and SW62 cells. Diseases such as Retinal Arterial Macroaneurysm With Supravalvular Pulmonic Stenosis and Diabetic Angiopathy are associated with IGFBP7.

IGFBP7 Protein (4)

    IGFBP7 Antibody (9)

      IGFBP7 ELISA 试剂盒(即用型)& ELISA 抗体对套装(非即用型)(2)

      IGFBP7 cDNA Clone (26)

      NM_001553.1

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_008048.3

      克隆载体 cDNA 产品

      In lentiviral vector

      IGFBP7 qPCR Primer (1)

      IGFBP7 Lysate (4)

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        IGFBP7 分子背景

        Insulin-like growth factor-binding protein 7 (IGFBP7) is a member of the IGFBP family. It has been identified in colorectal adenocarcinoma (CRC) cell lines. The Insulin-like growth factor-binding protein also known as IGFBP serves as a carrier protein for Insulin-like growth factor 1. IGFBPs are distinct but are sharing regions with strong homology. All members of the IGFBP family bind IGF-I and IGF-II with about equal affinity. Insulin-like growth factor (IGF) binding proteins (IGFBPs) have been shown to either inhibit or enhance the action of IGF or act in an IGF-independent manner in the prostate. IGFBP7 could inhibit cell growth, decrease soft agar colony formation activity, and induce apoptosis in RKO and SW620 cells. There is mounting evidence that the structure of the IGFBP proteins plays a key role in the regulation of IGF bioavailability, by modulating its molecular size, capillary membrane permeability, target tissue specificity, cell membrane adherence, and IGF affinity.

        IGFBP7 参考文献

        • Oh Y, et al. (1996) Synthesis and characterization of insulin-like growth factor-binding protein (IGFBP)-7. Recombinant human mac25 protein specifically binds IGF-I and -II. J Biol Chem. 271(48): 30322-5.
        • Wilson EM, et al. (1997) Generation and characterization of an IGFBP-7 antibody: identification of 31kD IGFBP-7 in human biological fluids and Hs578T human breast cancer conditioned media. J Clin Endocrinol Metab. 82(4): 1301-3.
        • Lin J, et al. (2007) Methylation patterns of IGFBP7 in colon cancer cell lines are associated with levels of gene expression. J Pathol. 212(1): 83-90.

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