IGSF3 Proteins, Antibodies, cDNA Clones Research Reagents

IGSF3 (Immunoglobulin Superfamily Member 3, also known as V8; LCDD; EWI-3), located on 1p13.1, is a Protein Coding gene. The gene produces a 135196 Da protein composed of 1194 amino acids. IGSF3 is a single-pass type I membrane protein that belongs to the EWI subfamily of the Ig superfamily of molecules. IGSF3 has an overall structural similarity and strong sequence similarity to V7, a human leukocyte surface protein. Diseases such as Lacrimal Duct Defect and Gastrointestinal Tularemia are associated with IGSF3.

IGSF3 Protein (1)

    IGSF3 Antibody (8)

      IGSF3 cDNA Clone (13)

      NM_001007237.1

      克隆载体 cDNA 产品

      In lentiviral vector

      IGSF3 qPCR Primer (1)

      IGSF3 Lysate (1)

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        IGSF3 分子背景

        Immunoglobulin superfamily member 3 (IGSF3), also known as Glu-Trp-Ile EWI motif-containing protein 3, IgSF3 and EWI-3 and IGSF3, is a single-pass type I membrane protein that belongs to the EWI subfamily of the Ig superfamily of molecules. IGSF3 has an overall structural similarity and strong sequence similarity to V7, a human leukocyte surface protein. IGSF3 contains eight Ig-like C2-type (immunoglobulin-like) domains. IGSF3 is expressed in a wide range of tissues with high expression in the placenta, kidney, and lung. EWI-2 is part of a novel Ig subfamily that includes EWI-F (F2alpha receptor regulatory protein (FPRP), CD9P-1 ), EWI-3 (IGSF3), and EWI-101 (CD101). All four members of this Ig subfamily contain a Glu-Trp-Ile (EWI) motif not seen in other Ig proteins. Human IGSF3 shares 92 % aa identity with mouse IGSF3.

        IGSF3 参考文献

        • Saupe S, et al. (1998) Molecular cloning of a human cDNA IGSF3 encoding an immunoglobulin-like membrane protein: expression and mapping to chromosome band 1p13. Genomics. 52(3): 305-11.
        • Lazaar AL, et al. (2001) VCAM-1 activates phosphatidylinositol 3-kinase and induces p120Cbl phosphorylation in human airway smooth muscle cells. J Immunol. 166(1): 155-61.
        • Wetzel A, et al. (2004) Human Thy-1 (CD90) on activated endothelial cells is a counterreceptor for the leukocyte integrin Mac-1 (CD11b/CD18). J Immunol. 172(6): 3850-9.

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