IHC Antibody Biological Target


Immunohistochemistry is the localization of antigens or proteins in tissue sections by the use of labeled antibodies as specific reagents through antigen-antibodyinteractions. Immunohistochemical antibody is widely used in the diagnosis of abnormal cells such as those found in cancerous tumors. Immunohistochemical antibody is also widely used in basic research to understand the distribution and localization of biomarkers and differentially expressed proteins in different parts of a biological tissue.
Biological target is very critical to drug discovery, drug development and disease diagnosis. Based on published estimates, there are approximately 1100 host biological targets and 200 pathogen biological targets. Among them, about one third is therapeutic affect-mediating target (also known as drug target). According to their funtions in signaling pathways, host biological targets can be classified into receptors, enzymes, transporters, and other molecules. The best-known receptor family is G protein-cou¬pled receptors (GPCRs), followed by receptor tyrosine kinases and ligand-gated ion channels; while the most famous enzyme family is hydrolases, then oxidoreductases and transferases. Pathogen biological targets in Sino Biological mainly come from virus (e.g. influenza virus, HIV, EBOV, coronavirus, RSV, and cytomegalovirus), bacteria (e.g. C. perfringens, Listeria monocytogenes, and M. viridifaciens), and parasite (e.g. plasmodium falciparum). Biological target reagents can be used in pharmaceutical industry and academic biomedical research for immunomodulation, inflammation, cardiovascular diseases, central nervous system (CNS) and cancer etc.