IL-1 alpha/IL1A Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

IL1A (Interleukin 1 Alpha, also known as IL1; IL-1A; IL1F1; IL1-ALPHA; IL-1 alpha), located on 2q14.1, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, and rat. The gene produces a 30607 Da protein composed of 271 amino acids. The protein encoded by this gene is a member of the interleukin 1 cytokine family. Diseases such as Arthritis and Cholesteatoma Of the Middle Ear are associated with IL1A. The related pathways of IL1A include NF-KappaB Family Pathway and Diseases associated with the TLR signaling cascade.

All IL-1 alpha/IL1A Reagents

IL-1 alpha/IL1A Protein (4)

    IL-1 alpha/IL1A Antibody (9)

      IL-1 alpha/IL1A ELISA 试剂盒(即用型)& ELISA 抗体对套装(非即用型)(2)

      IL-1 alpha/IL1A cDNA Clone (65)

      NM_000575.3

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_010554.4

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_017019.1

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_001003157.2

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_001042757.1

      克隆载体 cDNA 产品

      In lentiviral vector

      IL-1 alpha/IL1A Lysate (1)

        IL-1 alpha/IL1A 分子背景

        IL-1 alpha is a member of the interleukin 1 cytokine family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation, and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. Cytokines can be classified into two groups: pro- and anti-inflammatory. Pro-inflammatory cytokines, including IFNgamma, IL-1, IL-6, and TNF-alpha, are predominantly derived from the innate immune cells and Th1 cells. Anti-inflammatory cytokines, including IL-10, IL-4, IL-13, and IL-5, are synthesized from Th2 immune cells. IL-1 alpha is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. It is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. IL-1 alpha stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity.

        IL-1 alpha/IL1A 参考文献

        • Nicklin MJ,et al. (1994) A physical map of the region encompassing the human interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist genes. Genomics. 19(2):382-4.
        • March CJ, et al. (1985) Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs. Nature. 315(6021):641-7.
        • Bankers-Fulbright JL, et al. (1996) Interleukin-1 signal transduction. Life Sci. 59(2):61-83.
        • Dinarello CA, et al. (1997) Induction of interleukin-1 and interleukin-1 receptor antagonist. Semin Oncol. 24 (3 Suppl 9):S9-81-S9-93.

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