IL-15 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

IL15 (Interleukin 15, also known as IL-15), located on 4q31.21, is a Protein Coding gene. The gene produces a 18086 Da protein composed of 162 amino acids. IL15 is a cytokine that affects T-cell activation and proliferation similarly to IL2. It is transcribed in a variety of cell types including fibroblasts, epithelial cells, and monocytes, but not primary T cells. Diseases such as Severe Combined Immunodeficiency, X-Linked, and T Cell Deficiency are associated with IL15. The related pathways of IL15 include PEDF Induced Signaling and AKT Signaling Pathway.

IL-15 Protein (3)

    IL-15 Antibody (6)

      IL-15 ELISA 试剂盒(即用型)& ELISA 抗体对套装(非即用型)(1)

      IL-15 cDNA Clone (52)

      NM_172174.2

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_008357.1

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_013129.2

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_001044731.1

      克隆载体 cDNA 产品

      In lentiviral vector

      IL-15 分子背景

      The protein encoded by the IL15 gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietic receptor subunits and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Alternatively, spliced transcript variants of this gene have been reported.

      IL-15 参考文献

      • Mongini PKA, Gupta R, Boyle E, et al. TLR-9 and IL-15 synergy promotes the in vitro clonal expansion of chronic lymphocytic leukemia B cells. Journal of immunology (Baltimore, Md : 1950). 2015;195(3):901-923.

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