IL-19 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

IL19 (Interleukin 19, also known as MDA1; NG.1; ZMDA1; IL-10C), located on 1q32.1, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, and rat. The gene produces a 20452 Da protein composed of 177 amino acids. IL19 belongs to the IL10 family of cytokines, which also includes IL20, MDA7, and IL22. The protein contains a signal peptide, 2 potential N-linked glycosylation sites, and 4 conserved cysteine residues necessary for correct folding of the IL10 monomer. Diseases such as Inflammatory Bowel Disease and Psoriasis are associated with IL19.

IL-19 Protein (2)

    IL-19 Antibody (4)

      IL-19 ELISA 试剂盒(即用型)& ELISA 抗体对套装(非即用型)(2)

      IL-19 cDNA Clone (26)

      XM_006529705.1

      克隆载体 cDNA 产品

      In lentiviral vector

      XM_001060482.2

      克隆载体 cDNA 产品

      In lentiviral vector

      IL-19 qPCR Primer (1)

      IL-19 Lysate (2)

        IL-19 分子背景

        The molecular features at the IL19 locus may modestly alter the establishment of HIV-1 infection. Interleukin (IL) 19, IL-20, and IL-24 belong to the IL-10 cytokine family and have been identified to play a role in the regulation of epidermal functions and inflammation. The expression of IL19 in biopsies of patients with active ulcerative colitis was increased compared with patients with quiescent ulcerative colitis and that colitis was attenuated in IL-19-deficient mice. The disruption of the epithelial barrier with dextran sodium sulfate leads to increased IL-19 expression. Attenuated colitis in IL-19-deficient animals was associated with reduced numbers of IL-6-producing macrophages in the inflamed colonic lamina propria. Microbial-driven expression of IL-19 by intestinal macrophages may contribute to the pathogenesis of inflammatory bowel disease.

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