IL-32 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

IL32 (Interleukin 32, also known as NK4; TAIF; TAIFa; TAIFb; TAIFc; TAIFd; IL-32beta; IL-32alpha; IL-32delta; IL-32gamma), located on 16p13.3, is a Protein Coding gene. The gene produces a 26676 Da protein composed of 234 amino acids. IL32 is regulated robustly by other major proinflammatory cytokines and is crucial to inflammation and immune responses. It belongs to the cytokine family. Diseases such as Pancreatic Cancer and Granulomatosis With Polyangiitis are associated with IL32. The related pathways of IL32 include PEDF Induced Signaling and the Innate Immune System.

IL-32 Protein (1)

    IL-32 Antibody (9)

      IL-32 ELISA 试剂盒(即用型)& ELISA 抗体对套装(非即用型)(2)

      IL-32 cDNA Clone (13)

      NM_004221.4

      克隆载体 cDNA 产品

      In lentiviral vector

      IL-32 qPCR Primer (1)

      IL-32 Lysate (1)

        IL-32 分子背景

        IL-32 is a recently discovered cytokine that induces various proinflammatory cytokines (TNF-alpha, IL-1beta, IL-6) and chemokines in both human and mouse cells through the NF-kappaB and p38 MAPK inflammatory signal pathways. It is regulated robustly by other major proinflammatory cytokines and is crucial to inflammation and immune responses. Four of the IL-32 isoforms (alpha, beta, gamma, and delta) are the most representative IL-32 transcripts, and the gamma isoform of IL-32 is the most active, although all isoforms are biologically active. IL-32, a cytokine produced mainly by T, natural killer, and epithelial cells induces significant amounts of TNFalpha and MIP-2 and increases the production of both cytokines in a dose-dependent manner. IL-32 has been implicated in inflammatory disorders, Mycobacterium tuberculosis infections, inflammatory bowel disease, and influenza A virus infection, as well as in some autoimmune diseases, such as rheumatoid arthritis, ulcerative colitis, and in the human stomach cancer, human lung cancer, and breast cancer tissues. Thus, IL-32 expression might be valuable as a biomarker for cancer.

        IL-32 参考文献

        • Felaco P, et al. (2009) IL-32: a newly-discovered proinflammatory cytokine. J Biol Regul Homeost Agents. 23(3): 141-7.
        • Kobayashi H, et al. (2009) Molecular characterization of IL-32 in human endothelial cells. Cytokine. 46(3): 351-8.
        • Meyer N, et al. (2010) IL-32 is expressed by human primary keratinocytes and modulates keratinocyte apoptosis in atopic dermatitis. J Allergy Clin Immunol. 125(4): 858-865.

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