IL-33 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

IL33 (Interleukin 33, also known as DVS27; IL1F11; NF-HEV; NFEHEV; C9orf26), located on 9p24.1, is conserved in chimpanzee, dog, cow, mouse, and rat. The gene produces a 30759 Da protein composed of 270 amino acids. The protein encoded by this gene is a cytokine that binds to the IL1RL1/ST2 receptor. IL33 is a pro-inflammatory protein and a chromatin-associated cytokine of the IL1 family with high sequence and structural similarity to IL1 and IL18. IL33 protein also plays a pivotal role in helminthic infection and allergic disorders.

IL-33 Protein (3)

    IL-33 Antibody (17)

      IL-33 ELISA 试剂盒(即用型)& ELISA 抗体对套装(非即用型)(1)

      IL-33 cDNA Clone (58)

      NM_033439.2

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_133775.2

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_001014166.1

      克隆载体 cDNA 产品

      In lentiviral vector

      XM_005581767.2

      In expression vector

      NM_001003180.1

      克隆载体 cDNA 产品

      In lentiviral vector

      IL-33 分子背景

      Interleukin 33 (IL-33), also known as DVS27 or NF-HEV (Nuclear Factor from High Endothelial Venules), is a pro-inflammatory protein and a chromatin-associated cytokine of the IL-1 family with high sequence and structural similarity to IL-1 and IL-18. IL-33 protein is expressed highly and rather selectively by high endothelial venule endothelial cells (HEVECs) in human tonsils, Peyer's patches, and lymph nodes. IL-33 protein has transcriptional regulatory properties, and the researches suggested that IL-33 is a dual-function protein that might act both as a cytokine and as an intracellular nuclear factor. As a type 2 cytokines, IL-33 protein also play a pivotal role in helminthic infection and allergic disorders.

      IL-33 参考文献

      • Iikura M, et al. (2007) IL-33 can promote survival, adhesion and cytokine production in human mast cells. Lab Invest. 87(10): 971-8.
      • Lamkanfi M, et al. (2009) IL-33 raises alarm. Immunity. 31(1): 5-7.

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